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Recombinant Human SORL1

Cat.No. : SORL1-29617TH
Product Overview : Recombinant fragment corresponding to amino acids 82-181 of Human SorLA with an N terminal proprietary tag; Predicted MWt 36.63 kDa.
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Description : This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded protein is translated as a preproprotein and likely plays roles in endocytosis and sorting. There may be an association between expression of this locus and Alzheimers Disease.
Protein length : 100 amino acids
Molecular Weight : 36.630kDa inclusive of tags
Source : Wheat germ
Tissue specificity : Expressed mainly in brain, where it is most abundant in the cerebellum, cerebral cortex and the occipital pole; low expression in the putamen and the thalamus. According to PubMed:9157966, found in spinal cord, testis, liver, kidney and pancreas with dete
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : SAALQPEPIKVYGQVSLNDSHNQMV VHWAGEKSNVIVALARDSLALARPK SSDVYVSYDYGKSFKKISDKLNFGL GNRSEAVIAQFYHSPADNKRYIFAD
Sequence Similarities : Belongs to the SORL1 family.Contains 5 BNR repeats.Contains 1 EGF-like domain.Contains 6 fibronectin type-III domains.Contains 11 LDL-receptor class A domains.Contains 5 LDL-receptor class B repeats.
Gene Name : SORL1 sortilin-related receptor, L(DLR class) A repeats containing [ Homo sapiens ]
Official Symbol : SORL1
Synonyms : SORL1; sortilin-related receptor, L(DLR class) A repeats containing; C11orf32, chromosome 11 open reading frame 32 , sortilin related receptor, L(DLR class) A repeats containing; sortilin-related receptor; gp250; LR11; LRP9; SorLA; SorLA 1;
Gene ID : 6653
mRNA Refseq : NM_003105
Protein Refseq : NP_003096
MIM : 602005
Uniprot ID : Q92673
Chromosome Location : 11q23.2-q24.4
Function : low-density lipoprotein particle binding; receptor activity; transmembrane signaling receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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08/14/2022

    Whether I need assistance in experimental design, troubleshooting, or data interpretation, they provide prompt and personalized support, ensuring that my research progresses smoothly and efficiently.

    11/02/2020

      This proactive approach not only aids in expanding my knowledge but also encourages continuous improvement and innovation in my experimental approach.

      10/15/2019

        The manufacturer's commitment to customer support and collaboration greatly enhances the overall research experience.

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