Recombinant Human SPG21, His-tagged

• Cat.No.: SPG21-30665TH
• Product Overview: Recombinant full length Human SPG21 fused to His-tag at N-terminus; amino acids 1-308 , 37.1kDa.

Specification

• Description: The protein encoded by this gene was identified by a two-hybrid screen using CD4 as the bait. It binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4. At least three different transcript variants encoding two different isoforms have been found for this gene.
• Conjugation: HIS
• Source: E. coli
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 20mM Tris HCl, pH 8.0
• Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MGEIKVSPDY NWFRGTVPLK KIIVDDDDSK IWSLYDAGPR SIRCPLIFLP PVSGTADVFF RQILALTGWG YRVIALQYPV YWDHLEFCDG FRKLLDHLQL DKVHLFGASL GGFLAQKFAE YTHKSPRVHS LILCNSFSDT SIFNQTWTAN SFWLMPAFML KKIVLGNFSS GPVDPMMADA IDFMVDRLES LGQSELASRL TLNCQNSYVE PHKIRDIPVT IMDVFDQSAL STEAKEEMYK LYPNARRAHL KTGGNFPYLC RSAEVNLYVQ IHLLQFHGTK YAAIDPSMVS AEELEVQKGS LGISQEEQ

Gene Information

• Gene Name: SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) [ Homo sapiens ]
• Official Symbol: SPG21
• Synonyms: SPG21; spastic paraplegia 21 (autosomal recessive, Mast syndrome); maspardin; ACP33; BM 019; GL010; MAST
• Gene ID: 51324
• mRNA Refseq: NM_001127889
• Protein Refseq: NP_001121361
• MIM: 608181
• Uniprot ID: Q9NZD8
• Chromosome Location: 15q21-q22
• Function: CD4 receptor binding