Recombinant Human Phosphodiesterase 7B, GST-tagged

• Cat.No.: PDE7B-446H
• Product Overview: Recombinant Human phosphodiesterase 7B, full length with N-terminal GST tag expressed in aBaculovirusinfected Sf9 cell expression system. MW= 66 kDa.

Specification

• Cat. No.: PDE7B-446H
• Description: The 3",5"-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3",5"-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5"-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a cAMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family.
• Source: Baculovirus infected Sf9 cell.
• Purity: >80%.
• Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
• Formulated In: 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 50% glycerol, and 3 mM DTT.
• Stability: >6 months at –80°C.

Gene Information

• Gene Name: PDE7B phosphodiesterase 7B [ Homo sapiens ]
• Synonyms: PDE7B; phosphodiesterase 7B; MGC88256; bA472E5.1; cAMP-specific 3",5"-cyclic phosphodiesterase 7B; EC 3.1.4.17; rolipram-insensitive phosphodiesterase type 7; high-affinity cAMP-specific 3",5"-cyclic phosphodiesterase
• Gene ID: 27115
• mRNA Refseq: NM_018945
• Protein Refseq: NP_061818
• MIM: 604645
• UniProt ID: Q9NP56
• Chromosome Location: 6q23-q24
• Pathway: Progesterone-mediated oocyte maturation; Purine metabolism; Signaling by GPCR
• Function: 3",5"-cyclic-AMP phosphodiesterase activity; hydrolase activity