Recombinant Rat Prolactin Receptor
Cat.No. : | Prlr-1797R |
- Specification
- Gene Information
- Related Products
Cat. No. : | Prlr-1797R |
Description : | Prolactin Receptor (PRLR) is a cytokine receptor superfamily that lacks an intrinsic kinase domain and relies on the cytoplasmic Jak tyrosine kinases to transduce signals. PRLR is required for the signaling and proliferation of prolactin. |
Source : | Mammalian cells |
Molecular Weight : | The predicted molecular weight of Recombinant Rat PRL is Mr 51 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 67-74 kDa. |
State Of Matter : | Lyophilized. |
Purity : | >90% by SDS Page and analyzed by silver stain. |
Endotoxin : | <1.0 EU/µg as determined by the LAL method. |
Biological Activity : | The biological activity of Rat PRL was determined by Measured by its ability to neutralize the rhProlactin-induced proliferation of the rat lymphoma Nb2-11 treated with 0.5 ng/mL of rhProlactin. |
Storage And Stability : | This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions. |
Gene Name : | Prlr prolactin receptor [ Rattus norvegicus ] |
Synonyms : | Prlr; prolactin receptor; RATPRLR; MGC105486 |
Gene ID : | 24684 |
mRNA Refseq : | NM_001034111 |
Protein Refseq : | NP_001029283 |
UniProt ID : | P05710 |
Chromosome Location : | 2q16 |
Pathway : | Cytokine-cytokine receptor interaction; Neuroactive ligand-receptor interaction; Jak-STAT signaling pathway |
Function : | peptide hormone binding; prolactin receptor activity; protein binding |
Products Types
◆ Recombinant Protein | ||
Prlr-721R | Recombinant Rat Prlr Protein, His-tagged | +Inquiry |
PRLR-4360R | Recombinant Rat PRLR Protein, His (Fc)-Avi-tagged | +Inquiry |
Prlr-7003R | Recombinant Rat Prlr protein(Met1-Asp229), His-tagged | +Inquiry |
PRLR-720H | Recombinant Human PRLR Protein, His-tagged | +Inquiry |
PRLR-135H | Recombinant Human PRLR Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
PRLR-1740RCL | Recombinant Rat PRLR cell lysate | +Inquiry |
PRLR-1451MCL | Recombinant Mouse PRLR cell lysate | +Inquiry |
PRLR-2722HCL | Recombinant Human PRLR cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionPRLR overexpression or dysregulation has been associated with breast cancer. It can promote cell proliferation and survival through aberrant signaling pathways.
Tissue-specific factors and the presence of co-receptors contribute to the diversity of PRLR signaling outcomes in different tissues and cell types.
The JAK-STAT signaling pathway is a primary pathway activated by PRLR. It involves the activation of Janus kinases (JAKs) and signal transducers and activators of transcription (STATs).
PRLR undergoes endocytosis upon ligand binding, and the internalized receptor-ligand complex is trafficked through intracellular compartments, influencing downstream signaling and receptor recycling.
Phosphorylation is a crucial post-translational modification of PRLR, affecting its activation and downstream signaling. Other modifications, such as glycosylation, also play roles.
Customer Reviews (3)
Write a reviewConsistent quality shines through—this protein has become indispensable.
This protein streamlines our experiments.
Fast shipping made this purchase convenient for our lab operations.
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