Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human TDGF1, Fc-tagged

Cat.No. : TDGF1-27821TH
Product Overview : Recombinant fragment, corresponding to amino acids 31-169 of Human Cripto1 fused to the Fc region of human IgG1 (aa 90-330). The chimeric protein was expressed in modified human 293 cells.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants.
Conjugation : Fc
Tissue specificity : Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts.
Biological activity : 200 ng/ml of this Chimera induces ERK1 and ERK2 phosphorylation in human umbilical vein endothelial (HUVEC) cells.
Form : Lyophilised:It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial.Following reconstitution short-term storage at 4°C is recommended, with longer-term storage in aliquots at -18 to -20°C. Repeated freeze thawing is not rec
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 10% Trehalose, 1% Human serum albumin
Storage : Store at +4°C.
Sequences of amino acids : Theoretical sequence:LGHQEFARPSRGYLAFRDDSIWPQE EPAI RPRSSQRVPPMGIQHSKELNRTCCL NGGTCMLGSFCAC PPSFYGRNCEHDVRKENCGSVPHDT WLPKKCSLCKCWH GQLRCFPQAFLPGCDGLVMDEHLVA SRTPELPPSGSSNTKVDKKVEPKSC DKTHTCPPCPAPELLGGPSVFLFPP KPK DTLMISRTPEVTCVVVDVSHEDPEV KFNWYVDGVEVHN AKTKPREEQYNSTYRVVSVLTVLHQ DWLNGKEYKCKVS NKALPAPIEKTISKAKGQPREPQVY TLPPSRDELTKNQ VSLTCLVKGFYPSDIAVEWESNGQP ENNYKTTPPVLDSDGSFFLYSKLTV DKSRWQQGNVFSCSVMHEALHNHYT QKS LSLSPGK
Sequence Similarities : Contains 1 EGF-like domain.
Gene Name : TDGF1 teratocarcinoma-derived growth factor 1 [ Homo sapiens ]
Official Symbol : TDGF1
Synonyms : TDGF1; teratocarcinoma-derived growth factor 1; CR; CRIPTO; Cripto 1;
Gene ID : 6997
mRNA Refseq : NM_001174136
Protein Refseq : NP_001167607
Uniprot ID : P13385
Chromosome Location : 3p21.31
Pathway : Developmental Biology, organism-specific biosystem; Glypican 1 network, organism-specific biosystem; Regulation of Signaling by NODAL, organism-specific biosystem; Signaling by NODAL, organism-specific biosystem;
Function : growth factor activity; protein binding; receptor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (5)

Ask a question
Is TDGF1 associated with any genetic disorders? 01/26/2021

Mutations in the TDGF1 gene have been linked to certain congenital disorders. Understanding these genetic associations can provide insights into the underlying mechanisms of these conditions.

How does TDGF1 influence neurodevelopment? 02/11/2020

TDGF1 has been found to play a role in neural development. It is involved in the specification of neural cell fate and the formation of the neural tube during embryogenesis.

Can TDGF1 be a target for drug development? 06/27/2019

Yes, efforts are underway to develop drugs that modulate TDGF1 activity. Targeting TDGF1 could potentially lead to novel therapies for conditions related to cell growth and differentiation.

In what ways does TDGF1 contribute to stem cell biology? 06/04/2019

TDGF1 is involved in the maintenance of pluripotency in embryonic stem cells. Understanding its role could enhance our ability to control and manipulate stem cells for therapeutic purposes.

How can TDGF1 be utilized in cancer diagnostics? 10/09/2016

Researchers are exploring the use of TDGF1 as a biomarker for certain cancers. Detection of elevated TDGF1 levels in patient samples may aid in early cancer diagnosis.

Customer Reviews (3)

Write a review
Reviews
01/13/2020

    the manufacturer can assist in sourcing complementary reagents and tools, such as specific antibodies or detection systems, to complement the use of TDGF1 protein in trials.

    03/26/2018

      manufacturers often have a wealth of knowledge and expertise in the field of TDGF1 protein research.

      08/29/2017

        They may offer educational resources such as technical guides, protocols, and application notes, which can aid researchers in understanding the principles, techniques, and potential applications of TDGF1 protein in their studies.

        Ask a Question for All TDGF1 Products

        Required fields are marked with *

        My Review for All TDGF1 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends