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Recombinant Human TFF1, His-tagged

Cat.No. : TFF1-27974TH
Product Overview : Recombinant full length Human Estrogen Inducible Protein pS2 with N terminal His tag; 81 amino acids with tag, Predicted MWt 9.0 kDa.
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Description : Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.
Protein length : 60 amino acids
Conjugation : HIS
Molecular Weight : 9.000kDa inclusive of tags
Source : E. coli
Tissue specificity : Found in stomach, with highest levels in the upper gastric mucosal cells (at protein level). Detected in goblet cells of the small and large intestine and rectum, small submucosal glands in the esophagus, mucous acini of the sublingual gland, submucosal g
Form : Liquid
Purity : >90% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 20% Glycerol, 20mM Tris HCl, 100mM Sodium chloride, 1mM DTT, 0.1mM PMSF, pH 8.0
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids : MGSSHHHHHHSSGLVPRGSHMEAQT ETCTVAPRERQNCGFPGVTPSQCAN KGCCFDDTVRGVPWCFYPNTIDVPP EEECEF
Sequence Similarities : Contains 1 P-type (trefoil) domain.
Gene Name : TFF1 trefoil factor 1 [ Homo sapiens ]
Official Symbol : TFF1
Synonyms : TFF1; trefoil factor 1; BCEI, breast cancer, estrogen inducible sequence expressed in; D21S21; HP1.A; HPS2; pNR 2; pS2;
Gene ID : 7031
mRNA Refseq : NM_003225
Protein Refseq : NP_003216
MIM : 113710
Uniprot ID : P04155
Chromosome Location : 21q22.3
Pathway : FOXA1 transcription factor network, organism-specific biosystem;
Function : growth factor activity; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there targeted therapies based on FGFR3 in cancer treatment? 01/22/2021

Yes, FGFR3-targeted therapies are being developed for cancer treatment, particularly for patients with FGFR3 mutations.

What clinical applications are there for FGFR3 in cancer diagnosis? 10/14/2020

FGFR3 testing can aid in diagnosing specific types of cancer, especially bladder cancer, where FGFR3 mutations are prevalent.

How is FGFR3 targeted in cancer therapy? 06/06/2020

FGFR3-targeted therapies may involve small molecule inhibitors or monoclonal antibodies that specifically block the activity of mutated FGFR3.

How is FGFR3 associated with cancer? 11/21/2018

Mutations in the FGFR3 gene can lead to the development of certain cancers, including bladder cancer and multiple myeloma.

Is FGFR3 testing routinely conducted in cancer diagnosis? 02/24/2018

FGFR3 testing is becoming more common, especially in cases where specific cancers associated with FGFR3 mutations are suspected.

Customer Reviews (3)

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Reviews
08/18/2022

    TFF1 protein is highly recommended for scientific research applications, especially in ELISA assays and protein electron microscopy structure analysis.

    11/01/2020

      Its versatility in various biological applications, coupled with its compatibility with diverse techniques, makes it a preferred reagent for researchers in the field.

      07/28/2017

        Scientists who have employed TFF1 protein in their experiments have praised its outstanding performance and reliability.

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