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Recombinant Human TGM2, His-tagged

Cat.No. : TGM2-30353TH
Product Overview : Recombinant full length human Transglutaminase 2 produced in SF9 with 6x His-tag, 78,018 Dalton.
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  • Gene Information
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Description : Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene.
Conjugation : HIS
Form : Liquid
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 20% Glycerol, 320mM Sodium chloride, 16mM HEPES, pH 8.0
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities : Belongs to the transglutaminase superfamily. Transglutaminase family.
Gene Name : TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) [ Homo sapiens ]
Official Symbol : TGM2
Synonyms : TGM2; transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase); protein-glutamine gamma-glutamyltransferase 2; TGC;
Gene ID : 7052
mRNA Refseq : NM_004613
Protein Refseq : NP_004604
MIM : 190196
Uniprot ID : P21980
Chromosome Location : 20q12
Pathway : Huntingtons disease, organism-specific biosystem; Huntingtons disease, conserved biosystem; Thromboxane A2 receptor signaling, organism-specific biosystem;
Function : GTP binding; metal ion binding; protein binding; protein domain specific binding; protein-glutamine gamma-glutamyltransferase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there diagnostic applications of TGM2 in clinical settings? 02/28/2021

TGM2 levels and activity can serve as diagnostic markers in certain conditions, providing insights into the progression and severity of diseases.

How does TGM2 influence cardiovascular health? 01/26/2021

TGM2 has been associated with cardiovascular diseases, contributing to the development of atherosclerosis and vascular calcification.

How does TGM2 contribute to fibrosis in organ tissues? 10/25/2020

TGM2 plays a role in fibrosis by promoting the cross-linking of extracellular matrix proteins, contributing to tissue stiffness and impaired organ function.

How does TGM2 affect inflammation and immune responses? 09/17/2020

TGM2 is involved in modulating inflammation and immune responses, influencing processes such as cytokine production and leukocyte adhesion.

Are there genetic mutations related to TGM2 that impact clinical outcomes? 07/08/2017

Genetic variations in TGM2 have been identified, and certain mutations may influence susceptibility to specific diseases or alter the enzyme's functionality.

Customer Reviews (3)

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Reviews
12/21/2020

    The TGM2 protein has demonstrated its efficacy in protein electron microscopy structure analysis.

    03/30/2020

      Whether utilized in protein-protein interaction studies or enzymatic assays, this protein exhibits robust performance, enabling accurate data generation and analysis.

      07/19/2018

        This cutting-edge technique allows for the visualization and characterization of protein structures at the atomic level, providing insights into their function and potential therapeutic targets.

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