Recombinant Human PTPRN, GST-tagged

• Cat.No.: PTPRN-457H
• Product Overview: Protein tyrosine phosphatase. (PTP-IA2, ICA-PTP IA2 gel512), Catalytic domain, (a.a. 693-979), with N-terminal GST tag, MW=58.8 kDa, expressed in an E.coli expression system.

Specification

• Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.
• Source: E.coli
• Species: Human
• Tag: GST
• Form: 25 mM Tris-HCl, pH 8.0, 75 mM NaCl, 0.05% Tween-20, 50% glycerol, 2 mM EDTA, 1 mM DTT, and 10 mM glutathione.
• Purity: ≥ 95%
• Applications: Suitable for use as an immunogen, in binding assays or as an antigen in autoimmune assays.
• Storage: >6 months at –80°C

Gene Information

• Gene Name: PTPRN protein tyrosine phosphatase, receptor type, N [ Homo sapiens (human) ]
• Official Symbol: PTPRN
• Synonyms: PTPRN; IA2; IA-2; ICA512; R-PTP-N; IA-2/PTP; protein tyrosine phosphatase, receptor type, N; receptor-type tyrosine-protein phosphatase-like N; ICA 512; PTP IA-2; islet cell antigen 2; islet cell antigen 512; islet cell autoantigen 3; protein tyrosine phosphatase-like N; EC 3.1.3.48
• Gene ID: 5798
• mRNA Refseq: NM_002846
• Protein Refseq: NP_002837
• MIM: 601773
• UniProt ID: Q16849
• Chromosome Location: 2q35-q36.1
• Pathway: Type I diabetes mellitus
• Function: GTPase binding; protein binding; spectrin binding