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Recombinant Human TNFRSF10B, Fc-tagged

Cat.No. : TNFRSF10B-27023TH
Product Overview : Recombinant fragment corresponding to amino acids 52-212 of Human DR5 fused to the Fc portion of Human IgG1; MWt 50 kDa .
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  • Gene Information
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Description : The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene.
Protein length : 161 amino acids
Conjugation : Fc
Molecular Weight : 50.000kDa inclusive of tags
Source : HEK 293 cells
Tissue specificity : Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLa S3, K562, HL-60, SW480, A549 and G361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, p
Biological activity : Blocks Human or Mouse TRAIL activity in a concentration of 1-10μg/ml. Binds to Human and Mouse TRAIL.
Form : Lyophilised:Reconstitute with 50μl sterile water to give a final concentration of 1mg/ml.
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: PBS
Storage : Store at -20°C, Stable for 6 months at -20°C
Sequence Similarities : Contains 1 death domain.Contains 3 TNFR-Cys repeats.
Gene Name : TNFRSF10B tumor necrosis factor receptor superfamily, member 10b [ Homo sapiens ]
Official Symbol : TNFRSF10B
Synonyms : TNFRSF10B; tumor necrosis factor receptor superfamily, member 10b; tumor necrosis factor receptor superfamily member 10B; CD262; DR5; KILLER; TRAIL R2; TRICK2A; TRICKB;
Gene ID : 8795
mRNA Refseq : NM_003842
Protein Refseq : NP_003833
MIM : 603612
Uniprot ID : O14763
Chromosome Location : 8p22-p21
Pathway : Activation of Pro-Caspase 8, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Apoptosis, organism-specific biosystem;
Function : TRAIL binding; cysteine-type endopeptidase activator activity involved in apoptotic process; protein binding; receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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How does TNFRSF10B activation induce apoptosis in cancer cells? 03/09/2023

Activation of TNFRSF10B triggers apoptotic pathways, leading to programmed cell death in cancer cells.

Is TNFRSF10B involved in other diseases besides cancer? 04/19/2021

TNFRSF10B has been implicated in certain autoimmune diseases and neurodegenerative disorders, highlighting its diverse roles in various physiological processes.

Can TNFRSF10B be used as a diagnostic marker for cancer? 03/08/2019

TNFRSF10B expression levels may serve as a potential diagnostic marker for certain cancers, aiding in cancer detection and prognosis.

In what types of cancer is TNFRSF10B expression altered? 03/19/2017

TNFRSF10B expression is often altered in various cancers, including breast cancer, colorectal cancer, and lung cancer.

Are there any side effects associated with targeting TNFRSF10B in cancer treatment? 06/06/2016

Side effects may occur, and ongoing research aims to minimize these effects while maximizing the therapeutic benefits of targeting TNFRSF10B.

Customer Reviews (3)

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Reviews
08/11/2020

    The combination of high-quality TNFRSF10B protein and excellent technical support provided by the manufacturer makes them the ideal choice for my research.

    10/07/2018

      The manufacturer's extensive experience and expertise in the field of TNFRSF10B protein research make them a trusted partner.

      03/04/2017

        The manufacturer's commitment to providing excellent technical support is highly valuable.

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