Recombinant Human TNFRSF12A, Fc-tagged

• Cat.No.: TNFRSF12A-30127TH
• Product Overview: Recombinant fragment: EQAPGTAPCSRGSSWSADL D KCMDCASC RA RPHSDFC LGC AAAPPA PFRL LWP , corresponding to amino acids 28-80 of Human TWEAKR

Specification

• Description: Tumor necrosis factor receptor superfamily member 12A is a protein that in humans is encoded by the TNFRSF12A gene.
• Conjugation: Fc
• Source: E. coli
• Tissue specificity: Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas.
• Biological activity: Biological Activity : Determined by its ability to inhibit TWEAK-induced weak cell death of HT29 cells. The expected ED50 for this effect is 1.0-3.0 μg/ml.
• Form: Lyophilised:Reconstitute to 1mg/ml in sterile water.
• Storage: The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C.
• Sequences of amino acids: EQAPGTAPCS RGSSWSADLD KCMDCASCRA RPHSDFCLGC AAAPPAPFRL LWP
• Sequence Similarities: Contains 1 TNFR-Cys repeat.

Gene Information

• Gene Name: TNFRSF12A tumor necrosis factor receptor superfamily, member 12A [ Homo sapiens ]
• Official Symbol: TNFRSF12A
• Synonyms: TNFRSF12A; tumor necrosis factor receptor superfamily, member 12A; tumor necrosis factor receptor superfamily member 12A; CD266; FN14; TweakR
• Gene ID: 51330
• mRNA Refseq: NM_016639
• Protein Refseq: NP_057723
• MIM: 605914
• Uniprot ID: Q9NP84
• Chromosome Location: 16p13.3
• Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem
• Function: protein binding; receptor activity