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Recombinant Human TNFSF15, His-tagged

Cat.No. : TNFSF15-31532TH
Product Overview : Recombinant full length Human TL1A, secreted form with an N terminal His tag; 201 amino acids, Predicted MWt 22.7kDa.
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Description : The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene.
Protein length : 180 amino acids
Conjugation : HIS
Molecular Weight : 22.700kDa inclusive of tags
Source : E. coli
Tissue specificity : Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon.
Form : Liquid
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 50% Glycerol, 0.2M Sodium chloride, 20mM Tris HCl, 1mM DTT, pH 8.0
Storage : Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids : MGSSHHHHHHSSGLVPRGSHMLKGQ EFAPSHQQVYAPLRADGDKPRAHLT VVRQTPTQHFKNQFPALHWEHELGL AFTKNRMNYTNKFLLIPESGDYFIY SQVTFRGMTSECSEIRQAGRPNKPD SITVVITKVTDSYPEPTQLLMGTKS VCEVGSNWFQPIYLGAMFSLQEGDK LMVNVSDISLVDYTKEDKTFFGAFL L
Sequence Similarities : Belongs to the tumor necrosis factor family.
Gene Name : TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 [ Homo sapiens ]
Official Symbol : TNFSF15
Synonyms : TNFSF15; tumor necrosis factor (ligand) superfamily, member 15; tumor necrosis factor ligand superfamily member 15; MGC129934; MGC129935; TL1; TL1A; TNF ligand related molecule 1; TNF superfamily ligand TL1A; vascular endothelial cell growth inhibitor; va
Gene ID : 9966
mRNA Refseq : NM_005118
Protein Refseq : NP_005109
MIM : 604052
Uniprot ID : O95150
Chromosome Location : 9q32
Pathway : Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Senescence and Autophagy, organism-specific biosystem;
Function : cytokine activity; death receptor binding; receptor binding; tumor necrosis factor receptor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does TNFSF15 interact with other components of the immune system? 11/09/2020

TNFSF15 interacts with receptors on immune cells, influencing their activity and contributing to the overall regulation of immune responses.

Are there any current clinical trials targeting TNFSF15 for autoimmune disease treatments? 07/31/2017

Several clinical trials are underway to evaluate the efficacy and safety of therapies targeting TNFSF15 in autoimmune diseases.

Are there any diagnostic implications of TNFSF15 in autoimmune disorders? 01/07/2017

TNFSF15 levels may serve as a biomarker for certain autoimmune conditions, aiding in the diagnosis and monitoring of disease progression.

Can TNFSF15 be a potential target for novel drug development in autoimmune diseases? 12/06/2016

TNFSF15 is considered a promising target for drug development, and ongoing research aims to identify compounds that modulate its activity effectively.

How does TNFSF15 contribute to the pathogenesis of inflammatory bowel disease (IBD)? 05/24/2016

In IBD, TNFSF15 is believed to be involved in the inflammation process, contributing to the chronic nature of the disease.

Customer Reviews (3)

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03/21/2022

    They keep up with the latest research findings and continually refine their product based on customer feedback and emerging scientific trends.

    05/01/2021

      Their prompt assistance and prompt response can swiftly resolve any challenges, enabling smooth experimentation and maintaining the integrity of the results.

      10/01/2017

        Their knowledgeable support team is well-equipped to address specific inquiries, suggest experimental protocols, and provide guidance throughout the entire research process.

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