Recombinant Human SMURF2, FLAG-tagged
Cat.No. : | SMURF2-468H |
Product Overview : | Recombinant Human SMURF2 (amino-acids 130-end) was expressed in a Baculovirus infected Sf9 cell expression system with N-terminal FLAG tag, MW= 72 kDa. |
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Cat. No. : | SMURF2-468H |
Description : | SMURF2 has been shown to interact with Mothers against decapentaplegic homolog 7, SCYE1, SMURF1, Mothers against decapentaplegic homolog 3, Ubiquitin C, Mothers against decapentaplegic homolog 1 and Mothers against decapentaplegic homolog 2. |
Source : | Sf9. |
Formulated In : | 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 100 μg/ml FLAG peptide, 20% glycerol, and 3 mM DTT. |
Application : | Useful in conjunction with E1 and E2 for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
Purity : | > 80%. |
Stability : | >6 months at -80°C. |
Publication : |
KRAS Protein Stability Is Regulated through SMURF2: UBCH5 Complex-Mediated β-TrCP1 Degradation1,2 (2014)
Mutant EGFR is a preferred SMURF2 substrate of ubiquitination: role in enhanced receptor stability and TKI sensitivity (2020)
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Gene Name : | SMURF2 SMAD specific E3 ubiquitin protein ligase 2 [ Homo sapiens ] |
Synonyms : | SMAD specific E3 ubiquitin protein ligase 2; MGC138150; DKFZp686F0270; SMURF2; E3 ubiquitin ligase SMURF2; EC 6.3.2.-; hSMURF2; SMAD ubiquitination regulatory factor 2; SMAD-specific E3 ubiquitin-protein ligase 2 |
Gene ID : | 64750 |
mRNA Refseq : | NM_022739 |
Protein Refseq : | NP_073576 |
MIM : | 605532 |
UniProt ID : | Q9HAU4 |
Chromosome Location : | 17q22-q23 |
Pathway : | Endocytosis; TGF-beta signaling pathway; Ubiquitin mediated proteolysis; Signaling by BMP; Signaling by TGF beta |
Function : | acid-amino acid ligase activity; identical protein binding; ligase activity; ubiquitin-protein ligase activity |
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SMURF2-0441H | Recombinant Human SMURF2 Protein (S2-E748), Tag Free | +Inquiry |
SMURF2-2050H | Recombinant Human SMURF2 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
SMURF2-1646HCL | Recombinant Human SMURF2 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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