Recombinant Human TRIB3

• Cat.No.: TRIB3-30123TH
• Product Overview: Recombinant full length Human TRIB3 with proprietary tag; Predicted MWt 65.12.

Specification

• Description: The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1.
• Protein length: 358 amino acids
• Molecular Weight: 65.120kDa inclusive of tags
• Source: Wheat germ
• Tissue specificity: Highest expression in liver, pancreas, peripheral blood leukocytes and bone marrow. Also highly expressed in a number of primary lung, colon and breast tumors. Expressed in spleen, thymus, and prostate and is undetectable in other examined tissues, includ
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.79% Tris HCl, 0.31% Glutathione
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MRATPLAAPAGSLSRKKRLELDDNL DTERPVQKRARSGPQPRLPPCLLPL SPPTAPDRATAVATASRLGPYVLLE PEEGGRAYRALHCPTGTEYTCKVYP VQEALAVLEPYARLPPHKHVARPTE VLAGTQLLYAFFTRTHGDMHSLVRS RHRIPEPEAAVLFRQMATALAHCHQ HGLVLRDLKLCRFVFADRERKKLVL ENLEDSCVLTGPDDSLWDKHACPAY VGPEILSSRASYSGKAADVWSLGVA LFTMLAGHYPFQDSEPVLLFGKIRR GAYALPAGLSAPARCLVRCLLRREP AERLTATGILLHPWLRQDPMPLAPT RSHLWEAAQVVPDGLGLDEAREEEG DREVVLYG
• Sequence Similarities: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.Contains 1 protein kinase domain.

Gene Information

• Gene Name: TRIB3 tribbles homolog 3 (Drosophila) [ Homo sapiens ]
• Official Symbol: TRIB3
• Synonyms: TRIB3; tribbles homolog 3 (Drosophila); C20orf97, chromosome 20 open reading frame 97; tribbles homolog 3; dJ1103G7.3; TRB3
• Gene ID: 57761
• mRNA Refseq: NM_021158
• Protein Refseq: NP_066981
• MIM: 607898
• Uniprot ID: Q96RU7
• Chromosome Location: 20p13-p12.2
• Pathway: Activation of PKB, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Adipogenesis, organism-specific biosystem; CD28 co-stimulation, organism-specific biosystem; CD28 dependent PI3K/Akt signaling, organism-specific biosystem
• Function: ATP binding; NOT kinase activity; protein binding; protein kinase binding; protein kinase binding