Recombinant Human UNC5B, Fc-tagged
Cat.No. : | UNC5B-31670TH |
Product Overview : | Recombinant fragment of Human UNC5B fused at the C terminus to the Fc portion of Human IgG1; mwt: 80 kDa by SDS PAGE. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene. |
Protein length : | 336 amino acids |
Conjugation : | Fc |
Molecular Weight : | 80.000kDa |
Source : | HEK 293 cells |
Tissue specificity : | Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney and hematopoietic and immune tissues. |
Biological activity : | Binds to Mouse and Human Netrin 1. |
Form : | Liquid |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: PBS |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. |
Sequence Similarities : | Belongs to the unc-5 family.Contains 1 death domain.Contains 1 Ig-like (immunoglobulin-like) domain.Contains 1 Ig-like C2-type (immunoglobulin-like) domain.Contains 2 TSP type-1 domains.Contains 1 ZU5 domain. |
Gene Name : | UNC5B unc-5 homolog B (C. elegans) [ Homo sapiens ] |
Official Symbol : | UNC5B |
Synonyms : | UNC5B; unc-5 homolog B (C. elegans); unc5 (C.elegans homolog) b; netrin receptor UNC5B; p53RDL1; UNC5H2; |
Gene ID : | 219699 |
mRNA Refseq : | NM_001244889 |
Protein Refseq : | NP_001231818 |
MIM : | 607870 |
Uniprot ID : | Q8IZJ1 |
Chromosome Location : | 10q22.2 |
Pathway : | Apoptosis, organism-specific biosystem; Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; |
Function : | netrin receptor activity; protein binding; receptor activity; |
Products Types
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Unc5b-039R | Recombinant Rat Unc5b Protein, hIgG/His-tagged | +Inquiry |
UNC5B-9917M | Recombinant Mouse UNC5B Protein, His (Fc)-Avi-tagged | +Inquiry |
UNC5B-634H | Recombinant Human UNC5B Protein, MYC/DDK-tagged | +Inquiry |
UNC5B-555H | Recombinant Human UNC5B protein(Met1-Pro363), hFc-tagged | +Inquiry |
◆ Lysates | ||
UNC5B-767RCL | Recombinant Rat UNC5B cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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