Recombinant Human Transforming Growth Factor, Beta 2

• Cat.No.: TGFB2-348H

Specification

• Cat. No.: TGFB2-348H
• Description: Transforming growth factor-beta 2 (TGF-β2) is a secreted protein known as a potent cytokine that modulates embryonic development, bone formation, mammary development, wound healing, hematopoiesis, cell cycle progression and the production of the extracellular matrix.
• Source: Mammalian cells
• Molecular Weight: The predicted molecular weight of Recombinant Human TGF-β2 is Mr 25 kDa.
• State Of Matter: Lyophilized.
• Purity: >97% by SDS Page and analyzed by silver stain.
• Endotoxin: <0.1 ng per 1 µg as determined by the LAL method.
• Biological Activity: The biological activity of Human Transforming Growth Factor Beta 2 is determined by its ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells. The ED50 was found to be <0.2 ng/ml, corresponding to a specific activity of >5 x 106 units/mg.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Gene Information

• Gene Name: TGFB2 transforming growth factor, beta 2 [ Homo sapiens ]
• Synonyms: TGFB2; transforming growth factor, beta 2; MGC116892; TGF-beta2; transforming growth factor, beta 2
• Gene ID: 7042
• mRNA Refseq: NM_001135599
• Protein Refseq: NP_001129071
• MIM: 190220
• UniProt ID: P61812
• Chromosome Location: 1q41
• Pathway: Cell cycle; Chronic myeloid leukemia; Cytokine-cytokine receptor interaction; Dilated cardiomyopathy; Hypertrophic cardiomyopathy (HCM); MAPK signaling pathway; Pathways in cancer; Renal cell carcinoma; TGF-beta signaling pathway; Hemostasis
• Function: beta-amyloid binding; cytokine activity; protein heterodimerization activity; growth factor activity; type II transforming growth factor beta receptor binding; receptor signaling protein serine/threonine kinase activity