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Recombinant Human VHL, His-tagged

Cat.No. : VHL-29832TH
Product Overview : Recombinant fragment, corresponding to amino acids 1-154 of Human Von Hippel Lindau protein. This protein includes a His-tag at the N-terminal end.
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Description : Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Conjugation : HIS
Source : E. coli
Tissue specificity : Expressed in the adult and fetal brain and kidney.
Form : Liquid
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: PBS, 2mM EDTA, 1mM DTT, pH 7.4
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequences of amino acids : MGSSHHHHHH SSGLVPRGSH MPRRAENWDE AEVGAEEAGV EEYGPEEDGG EESGAEESGPEESGPEELGA EEEMEAGRPR PVLRSVNSRE PSQVIFCNRS PRVVLPVWLN FDGEPQPYPTLPPGTGRRIH SYRGHLWLFR DAGTHDGLLV NQTELFVPSL NVDGQPIFAN ITLP
Gene Name : VHL von Hippel-Lindau tumor suppressor [ Homo sapiens ]
Official Symbol : VHL
Synonyms : VHL; von Hippel-Lindau tumor suppressor; von Hippel Lindau syndrome; von Hippel-Lindau disease tumor suppressor; VHL1;
Gene ID : 7428
mRNA Refseq : NM_000551
Protein Refseq : NP_000542
MIM : 608537
Uniprot ID : P40337
Chromosome Location : 3p25.3
Pathway : Adaptive Immune System, organism-specific biosystem; Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem;
Function : protein binding; transcription factor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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