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Recombinant Human XCL1

Cat.No. : XCL1-27983TH
Product Overview : Recombinant fragment, corresponding to amino acids 23-114 of Human Lymphotactin, 92 amino acids, 10kDa.
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  • Gene Information
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Description : This gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1.
Source : E. coli
Tissue specificity : Highest level in spleen, lower in peripheral leukocytes and very low levels in lung, colon and small intestine.
Biological activity : Biological Activity:The Biological activity is calculated by its ability to chemoattract human T cells at 10.0-100.0 ng/ml.
Form : Lyophilised:Reconstitute in sterile 18MO-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions.Upon reconstitution XCL1-27983TH should be stored at 4°C between 2-7 days and for future use below -18°C. For long term st
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: ddH20
Storage : Store at -20°C or lower.Aliquot to avoid repeated freezing and thawing.
Sequences of amino acids : The sequence of the first five N-terminal amino acids was determined and was found to be Gln-Ser-Glu-Val-Ser.
Sequence Similarities : Belongs to the intercrine gamma family.
Gene Name : XCL1 chemokine (C motif) ligand 1 [ Homo sapiens ]
Official Symbol : XCL1
Synonyms : XCL1; chemokine (C motif) ligand 1; LTN, SCYC1, small inducible cytokine subfamily C, member 1 (lymphotactin); lymphotactin; ATAC; LPTN; SCM 1; SCM 1a;
Gene ID : 6375
mRNA Refseq : NM_002995
Protein Refseq : NP_002986
MIM : 600250
Uniprot ID : P47992
Chromosome Location : 1q24.2
Pathway : Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem;
Function : chemokine activity; chemokine receptor binding; chemokine receptor binding; protein homodimerization activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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What is known about the regulation of XCL1 expression, and how do various stimuli modulate its secretion in the context of inflammatory responses and immune activation? 01/22/2022

XCL1 expression is regulated by various stimuli, including inflammatory signals. Understanding how these stimuli modulate XCL1 secretion provides insights into its dynamic role in immune activation.

How does XCL1 influence the differentiation and function of dendritic cells, and are there implications for the modulation of adaptive immune responses? 03/01/2021

XCL1 influences the differentiation and function of dendritic cells, affecting the priming and activation of T cells. Understanding these processes has implications for modulating adaptive immune responses in various contexts.

How does XCL1 contribute to the formation of immune synapses between dendritic cells and T cells, and what molecular events underlie this process? 07/14/2020

XCL1 is involved in the formation of immune synapses between dendritic cells and T cells. Molecular events include the coordinated expression of adhesion molecules and the release of other signaling molecules.

Can you discuss the molecular mechanisms through which XCL1 interacts with its receptor XCR1, and how this interaction influences immune cell function? 02/26/2019

XCL1 binds to its receptor XCR1, initiating intracellular signaling cascades. This interaction influences immune cell function by directing the migration and activation of specific immune cell subsets.

In infectious diseases, particularly viral infections, what evidence supports the involvement of XCL1 in the host immune response, and how might it influence the outcome of infections? 09/20/2018

XCL1 is implicated in the host immune response to viral infections. Its role in recruiting and activating immune cells may influence the outcome of infections, impacting viral clearance and immune memory.

Customer Reviews (3)

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Reviews
03/30/2022

    Consistent high quality, responsive customer service, and seamless delivery

    07/10/2019

      Commendable product quality, professional customer service, and punctual delivery.

      09/05/2018

        Outstanding product quality, swift delivery, and helpful customer service. Highly recommend!

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