Recombinant Human YWHAH, His-tagged

• Cat.No.: YWHAH-26007TH
• Product Overview: Recombinant full length Human 14-3-3 eta fused to N-Terminal His Tag; 266aa, 30.3kDa.

Specification

• Description: This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5 UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder.
• Protein length: 246 amino acids
• Conjugation: HIS
• Molecular Weight: 30.300kDa inclusive of tags
• Source: E. coli
• Tissue specificity: Expressed mainly in the brain and present in other tissues albeit at lower levels.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: pH: 8.00Constituent:0.32% Tris HCl
• Storage: Store at -20°C (dessicate conditions).
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MGDREQLLQR ARLAEQAERY DMASAMKAV TELNEPLSNE DRNLLSVAYK NVVGARRSSW RVISSIEQKT MADGNEKKLE KVKAYREKIE KELETVCNDV LSLLDKFLIK NCNDFQYESK VFYLKMKGDY YRYLAEVASG EKKNSVVEAS EAAYKEAFEI SKEQMQPTHP IRLGLALNFS VFYYEIQNAP EQACLLAKQA FDDAIAELDT LNEDSYKDST LIMQLLRDNL TLWTSDQQDE EAGEGN
• Sequence Similarities: Belongs to the 14-3-3 family.

Gene Information

• Gene Name: YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide [ Homo sapiens ]
• Official Symbol: YWHAH
• Synonyms: YWHAH; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide; YWHA1; 14-3-3 protein eta; 14 3 3 eta
• Gene ID: 7533
• mRNA Refseq: NM_003405
• Protein Refseq: NP_003396
• MIM: 113508
• Uniprot ID: Q04917
• Chromosome Location: 22q12.1-q13.1
• Pathway: Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, conserved biosystem
• Function: actin binding; enzyme binding; glucocorticoid receptor binding; insulin-like growth factor receptor binding; protein binding