Recombinant Human TRDMT1, GST-tagged

• Cat.No.: TRDMT1-512H
• Product Overview: Recombinant Human DNMT2, (a-a 2-292), with N-terminal GST tag expressed inbaculovirus. MW=71 kDa.

Specification

• Cat. No.: TRDMT1-512H
• Description: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a protein with similarity to DNA methyltransferases, but this protein does not display methyltransferase activity. The protein strongly binds DNA, suggesting that it may mark specific sequences in the genome. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Source: Baculovirus.
• Purity: >80%.
• Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
• Formulated In: 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20 and 10% glycerol.
• Stability: >6 months at –80°C.

Gene Information

• Gene Name: TRDMT1 tRNA aspartic acid methyltransferase 1 [ Homo sapiens ]
• Synonyms: TRDMT1; tRNA aspartic acid methyltransferase 1; DMNT2; DNMT2; PuMet; RNMT1; M.HsaIIP; DNA methyltransferase-2; DNA MTase homolog HsaIIP; DNA methyltransferase homolog HsaIIP; DNA (cytosine-5-)-methyltransferase 2; EC 2.1.1.29
• Gene ID: 1787
• mRNA Refseq: NM_004412
• Protein Refseq: NP_004403
• MIM: 602478
• UniProt ID: O14717
• Chromosome Location: 10p15.5
• Pathway: Cysteine and methionine metabolism; Metabolic pathways
• Function: DNA (cytosine-5-)-methyltransferase activity; RNA binding; methyltransferase activity; tRNA (cytosine-5-)-methyltransferase activity transferase activity; DNA binding