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Recombinant Human UBA1, GST-tagged

Cat.No. : UBA1-476H
Product Overview : Recombinant Human UBA1, amino acids 2-end with N-terminal FLAG tag expressed inSf9expression system. MW = 118kDa.
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Cat. No. : UBA1-476H
Description : Ubiquitin-like modifier activating enzyme 1, also known as UBA1, is an enzyme which in humans is encoded by the UBA1 gene. In non-primates, the gene UBE1, rather than the SRY gene, is commonly used for sexual determination.
Source : Sf9.
Purity : >65%.
Application : Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Formulated In : 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 30% glycerol, and 3 mM DTT.
Stability : >6 months at –80°C.
Gene Name : UBA1 ubiquitin-like modifier activating enzyme 1 [ Homo sapiens ]
Synonyms : UBA1; ubiquitin-like modifier activating enzyme 1; A1S9; A1ST; GXP1; UBE1; A1S9T; AMCX1; SMAX2; UBA1A; UBE1X; MGC4781; UBA1, ubiquitin-activating enzyme E1 homolog A; A1S9T and BN75 temperature sensitivity complementing; ubiquitin-activating enzyme E1; EC 6.3.2.19
Gene ID : 7317
mRNA Refseq : NM_003334
Protein Refseq : NP_003325
MIM : 314370
UniProt ID : P22314
Chromosome Location : Xp11.23
Pathway : Parkinson"s disease; Ubiquitin mediated proteolysis
Function : ATP binding; ligase activity; nucleotide binding; small protein activating enzyme activity; protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any clinical trials involving UBA1 as a target? 04/20/2023

Some early-phase clinical trials are exploring UBA1 as a potential target in the context of ALS and cancer.

How can UBA1 be targeted for therapeutic purposes? 09/19/2020

Targeting UBA1 with small molecules or gene therapy may provide a potential avenue for treating UBA1-related diseases.

How does UBA1 function in the cell? 12/04/2017

UBA1 activates ubiquitin, a small protein that tags other proteins for degradation by the proteasome.

What diseases are associated with UBA1 dysfunction? 07/19/2017

UBA1 dysfunction has been linked to neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) and certain types of cancer.

Can UBA1 be a diagnostic marker for ALS? 08/16/2016

Research suggests that altered UBA1 levels in the cerebrospinal fluid may be a potential biomarker for ALS diagnosis.

Customer Reviews (3)

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Reviews
07/02/2022

    The UBA1 protein comes highly recommended for its outstanding performance in various experimental applications.

    07/07/2019

      In ELISA assays, it has consistently exhibited exceptional reliability and accuracy, providing precise and reproducible results.

      05/13/2017

        Their prompt and knowledgeable guidance has been instrumental in effectively addressing my queries and optimizing the utilization of the UBA1 protein in my studies.

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