Recombinant Human Heat Shock 70kDa Protein 8

• Cat.No.: HSPA8-1809H
• Product Overview: Recombinant human HSC70 protein was expressed inE.coliand purified by using conventional chromatography techniques. MW = 73.1 kDa (666aa).

Specification

• Cat. No.: HSPA8-1809H
• Description: HSC70, also known as heat shock 70 kDa protein 8, belongs to the heat shock protein 70 family which contains both heat-inducible and constitutively expressed members. The latter are called heat-shock cognate proteins. This protein is a heat-shock cognate protein. HSC70 binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell.
• Source: E.coli.
• Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MSKGPAVGID LGTTYSCVGV FQHGKVEIIA NDQGNRTTPS YVAFTDTERL IGDAAKNQVA MNPTNTVFDA KRLIGRRFDD AVVQSDMKHW PFMVVNDAGR PKVQVEYKGE TKSFYPEEVS SMVLTKMKEI AEAYLGKTVT NAVVTVPAYF NDSQRQATKD AGTIAGLNVL RIINEPTAAA IAYGLDKKVG AERNVLIFDL GGGTFDVSIL TIEDGIFEVK STAGDTHLGG EDFDNRMVNH FIAEFKRKHK KDISENKRAV RRLRTACERA KRTLSSSTQA SIEIDSLYEG IDFYTSITRA RFEELNADLF RGTLDPVEKA LRDAKLDKSQ IHDIVLVGGS TRIPKIQKLL QDFFNGKELN KSINPDEAVA YGAAVQAAIL SGDKSENVQD LLLLDVTPLS LGIETAGGVM TVLIKRNTTI PTKQTQTFTT YSDNQPGVLI QVYEGERAMT KDNNLLGKFE LTGIPPAPRG VPQIEVTFDI DANGILNVSA VDKSTGKENK ITITNDKGRL SKEDIERMVQ EAEKYKAEDE KQRDKVSSKN SLESYAFNMK ATVEDEKLQG KINDEDKQKI LDKCNEIINW LDKNQTAEKE EFEHQQKELE KVCNPIITKL YQSAGGMPGG MPGGFPGGGA PPSGGASSGP TIEEVD
• Form: Liquid. In 20mM Tris buffer (pH 8.0) containing 10% glycerol.
• Purity: > 90% by SDS – PAGE.
• Concentration: 1 mg/ml (determined by Bradford assay).
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: HSPA8 heat shock 70kDa protein 8 [ Homo sapiens ]
• Synonyms: HSPA8; heat shock 70kDa protein 8; LAP1; HSC54; HSC70; HSC71; HSP71; HSP73; NIP71; HSPA10; MGC29929; MGC131511; LPS-associated protein 1; heat shock 70kD protein 8; heat shock 70kd protein 10; heat shock cognate protein 54; constitutive heat shock protein 70; heat shock cognate protein, 71-kDa; lipopolysaccharide-associated protein 1; N-myristoyltransferase inhibitor protein 71; Heat shock cognate 71 kDa protein; constitutive heat shock protein 70; heat shock 70kd protein 10
• Gene ID: 3312
• mRNA Refseq: NM_006597
• Protein Refseq: NP_006588
• MIM: 600816
• UniProt ID: P11142
• Chromosome Location: 11q24.1
• Pathway: Antigen processing and presentation; Endocytosis; MAPK signaling pathway
• Function: ATP binding; ATPase activity, coupled; nucleotide binding; unfolded protein binding