Recombinant Human S-phase Kinase-associated Protein 1

• Cat.No.: SKP1-1822H
• Product Overview: Recombinant human SKP1 protein was expressed inE.coliand purified by using conventional chromatography techniques. MW = 18 kDa (160aa).

Specification

• Cat. No.: SKP1-1822H
• Description: S-phase kinase-associated protein 1, also known as SKP1, is an F-box protein which functions as a substrate recognition component of the SCF ubiquitin ligase complex. It binds to proteins containing an F-box motif, such as cyclin F, S-phase kinase-associated protein 2, and other regulatory proteins involved in ubiquitin dependent proteolysis. It is also involved in the control of beta-catenin levels and the activity of beta-catenin dependent TCF transcription factors.
• Source: E.coli.
• Amino Acid Sequence: MPSIKLQSSD GEIFEVDVEI AKQSVTIKTM LEDLGMDDEG DDDPVPLPNV NAAILKKVIQ WCTHHKDDPP PPEDDENKEK RTDDIPVWDQ EFLKVDQGTL FELILAANYL DIKGLLDVTC KTVANMIKGK TPEEIRKTFN IKNDFTEEEE AQVGSTQFCL
• Form: Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 50mM NaCl, 10% glycerol.
• Purity: > 90% by SDS – PAGE.
• Concentration: 1 mg/ml (determined by Bradford assay).
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: SKP1 S-phase kinase-associated protein 1 [ Homo sapiens ]
• Synonyms: SKP1; S-phase kinase-associated protein 1; OCP2; p19A; EMC19; SKP1A; OCP-II; TCEB1L; MGC34403; organ of Corti protein 2; cyclin A/CDK2-associated p19; RNA polymerase II elongation factor-like protein OCP2; transcription elongation factor B (SIII), polypeptide 1-like; S-phase kinase-associated protein 1A (p19A); Cyclin A/CDK2-associated protein p19; p19skp1; RNA polymerase II elongation factor-like protein; Organ of Corti protein 2; OCP-2; Transcription elongation factor B; SIII; cyclin A/CDK2-associated p19
• Gene ID: 6500
• mRNA Refseq: NM_006930
• Protein Refseq: NP_008861
• MIM: 601434
• UniProt ID: P63208
• Chromosome Location: 5q31
• Pathway: Cell cycle; TGF-beta signaling pathway; Ubiquitin mediated proteolysis; Wnt signaling pathway
• Function: protein binding