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Recombinant Human Ciliary Neurotrophic Factor, His-tagged

Cat.No. : CNTF-08H
Product Overview : Recombinant human CNTF, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques(220 aa, 25 kDa).
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  • Gene Information
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Cat. No. : CNTF-08H
Description : CNTF (Ciliary neurotrophic factor) is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. This protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. CNTF protein is structurally related to leukemia inhibitory factor (LIF), interleukin-6 (IL-6), interleukin-11 (IL-11) and oncostatin M (OSM). It is localized in the cell nucleus subsequent to receptor binding.
Source : Escherichia Coli.
Formulation : Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT.
Molecular Weight : 25 kDa (220 aa).
Purity : > 95% by SDS – PAGE.
Concentration : 1 mg/ml (determined by Bradford assay).
Amino acid sequence : MGSSHHHHHH SSGLVPRGSH MAFTEHSPLT PHRRDLCSRS IWLARKIRSD LTALTESYVK HQGLNKNINL DSADGMPVAS TDQWSELTEA ERLQENLQAY RTFHVLLARL LEDQQVHFTP TEGDFHQAIH TLLLQVAAFA YQIEELMILL EYKIPRNEAD GMPINVGDGG LFEKKLWGLK VLQELSQWTV RSIHDLRFIS SHQTGIPARG SHYIANNKKM
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : CNTF ciliary neurotrophic factor [ Homo sapiens ]
Synonyms : HCNTF; CNTF; Ciliary Neurotrophic Factor; OTTHUMP00000174731; ciliary neurotrophic factor.
Gene ID : 1270
mRNA Refseq : NM_000614
Protein Refseq : NP_000605
MIM : 118945
UniProt ID : P26441
Chromosome Location : 11q12.2
Pathway : Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway.
Function : ciliary neurotrophic factor receptor binding; interleukin-6 receptor binding; protein binding.

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does CNTF affect glial cell function? 08/18/2021

CNTF plays a crucial role in regulating glial cell function. It can modulate astrocyte and oligodendrocyte differentiation, promote myelination, and regulate the release of neurotrophic factors from glial cells. CNTF also influences glial cell-mediated immune responses and their interaction with neurons in various pathological conditions.

What are the signaling pathways activated by CNTF in neurons and glial cells? 11/28/2020

CNTF activates multiple signaling pathways, including JAK/STAT, PI3K/AKT, and MAPK/ERK, in both neurons and glial cells. These pathways play crucial roles in regulating gene expression, cell survival, differentiation, and synaptic plasticity.

What is the role of CNTF in neuroinflammation? 09/08/2019

CNTF plays a significant role in modulating neuroinflammatory responses. It can regulate the activation and function of microglia and astrocytes, leading to the production of pro-inflammatory or anti-inflammatory factors. CNTF also influences the recruitment and activation of immune cells in the central nervous system.

How does CNTF affect synaptic plasticity? 10/22/2016

CNTF has been shown to modulate synaptic plasticity, which underlies learning and memory processes. It promotes the formation and stabilization of synapses, regulates neurotransmitter release, and influences synaptic strength and plasticity through its interaction with specific receptors and downstream signaling molecules.

What are the challenges in developing CNTF-based therapies? 10/16/2016

Developing CNTF-based therapies faces challenges such as the need for targeted delivery to specific brain regions, potential side effects due to systemic administration, and the need to optimize dosing and treatment regimens. Additionally, understanding the precise mechanisms of CNTF action and identifying suitable patient populations for treatment are important considerations.

How does CNTF promote neuronal survival and regeneration? 04/14/2016

CNTF exerts neuroprotective effects by promoting neuronal survival and regeneration through the activation of various intracellular signaling pathways. It enhances the expression of neurotrophic factors, regulates apoptosis-related genes, and stimulates axonal outgrowth and synaptic remodeling.

Can CNTF be a potential therapeutic approach for neurodegenerative diseases? 02/07/2016

CNTF shows promise as a potential therapeutic approach for neurodegenerative diseases, such as amyotrophic lateral sclerosis and retinal degeneration. Its neuroprotective and neurotrophic effects make it a potential candidate for promoting neuronal survival, preventing neurodegeneration, and improving functional recovery in these conditions.

Customer Reviews (3)

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Reviews
03/04/2020

    It is highly durable and meets the requirements for long-term experiments.

    06/02/2017

      A trusted aide, this reagent is instrumental on the path of scientific inquiry.

      09/01/2016

        Employing this protein reagent allows me to obtain precise structural information in protein interaction studies, offering critical insights for a deeper understanding of protein function.

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