Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human Ketohexokinase

Cat.No. : KHK-491H
Product Overview : Recombinant human Ketohexokinase was expressed inE.coliand purified by using conventional chromatography.
  • Specification
  • Gene Information
  • Related Products
Cat. No. : KHK-491H
Description : Ketohexokinase is an enzyme that catalyzes the phosphorylation of fructose to produce fructose-1-phosphate, leading to consumption of ATP, formation of AMP. This protein initiates first step in the metabolism of dietary fructose and is an important regulator of hepatic glucose metabolism. It is highly found in liver, renal cortex, and small intestine. Its deficiency causes the benign hereditary metabolic disorder essential fructosuria, leading to fructose being excreted in the urine.
Sequences of amino acids : MEEKQILCVG LVVLDVISLV DKYPKEDSEI RCLSQRWQRG GNASNSCTIL SLLGAPCAFM GSMAPGHVAD FVLDDLRRYS VDLRYTVFQT TGSVPIATVI INEASGSRTI LYYDRSLPDV SATDFEKVDL TQFKWIHIEG RNASEQVKML QRIDAHNTRQ PPEQKIRVSV EVEKPREELF QLFGYGDVVF VSKDVAKHLG FQSAEEALRG LYGRVRKGAV LVCAWAEEGA DALGPDGKLL HSDAFPPPRV VDTLGAGDTF NASVIFSLSQ GRSVQEALRF GCQVAGKKCG LQGFDGIV
Form : Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol
Molecular Weight : 32.7 kDa (298aa)
Purity : > 90% by SDS - PAGE
Concentration : 1 mg/ml (determined by Bradford assay)
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Pathways : Fructose and mannose metabolism; Metabolic pathways; Metabolism of carbohydrates
Gene Name : KHK ketohexokinase (fructokinase) [ Homo sapiens ]
Synonyms : KHK; ketohexokinase (fructokinase); ketohexokinase; EC 2.7.1.3; ketohexokinase; Hepatic fructokinase;
Gene ID : 3795
mRNA Refseq : NM_000221
Protein Refseq : NP_000212
MIM : 229800
UniProt ID : P50053
Chromosome Location : 2p23.3
Function : ATP binding; ketohexokinase activity; kinase activity; nucleotide binding; protein binding; transferase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (6)

Ask a question
How is the activity of KHK protein regulated? 10/15/2022

Activity of KHK protein is affected by many factors, including gene expression, hormone levels, nutritional status, etc. In addition, some small molecule compounds can also regulate the activity of KHK proteins.

What is the relationship between KHK protein and the occurrence and progression of disease? 05/02/2022

Some studies have shown that abnormal expression of the KHK protein may be related to the occurrence and progression of some diseases. For example, in some cancers, the expression level of the KHK protein may change. In addition, the KHK protein may also be a drug target for the treatment of these diseases.

How to use the activity of KHK protein for disease treatment? 07/06/2021

The activity of the KHK protein can be modulated by drugs or other small molecule compounds to treat diseases related to the KHK protein. For example, some drugs can inhibit the activity of the KHK protein to treat diseases associated with abnormal metabolism of ketone bodies

What diseases are mutations or abnormal expression of the KHK protein associated with? 03/11/2021

Some studies have shown that mutations or abnormal expression of the KHK protein may be related to some diseases, such as cancer, neurodegenerative diseases, etc. However, the specific association needs to be confirmed by further research.

How about the interaction between the KHK protein and other enzymes or proteins? 02/14/2021

The interaction between the KHK protein and other enzymes or proteins is complex. For example, it may interact with fatty acid synthase to co-catalyze the synthesis of ketone bodies. In addition, it may interact with some regulators to regulate its activity.

How to use KHK protein for disease diagnosis? 12/15/2019

The occurrence, progression, and prognosis of the disease can be assessed by examining the expression level, activity, and interaction of KHK protein with other proteins. These features can also be used to develop new biomarkers and drug targets.

Customer Reviews (3)

Write a review
Reviews
12/03/2020

    Due to the short half-life and high clearance characteristics of KHK, they can better adapt to the treatment needs of patients of different ages, providing patients with a safer and more effective treatment option.

    12/30/2019

      The stability of KHK is so good that it can be manipulated experimentally for long periods of time without compromising its performance and results.

      09/19/2019

        Reproducibility of the Western blot was significantly improved by using this protein.

        Ask a Question for All KHK Products

        Required fields are marked with *

        My Review for All KHK Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends