Recombinant Human Ketohexokinase
Cat.No. : | KHK-491H |
Product Overview : | Recombinant human Ketohexokinase was expressed inE.coliand purified by using conventional chromatography. |
- Specification
- Gene Information
- Related Products
Cat. No. : | KHK-491H |
Description : | Ketohexokinase is an enzyme that catalyzes the phosphorylation of fructose to produce fructose-1-phosphate, leading to consumption of ATP, formation of AMP. This protein initiates first step in the metabolism of dietary fructose and is an important regulator of hepatic glucose metabolism. It is highly found in liver, renal cortex, and small intestine. Its deficiency causes the benign hereditary metabolic disorder essential fructosuria, leading to fructose being excreted in the urine. |
Sequences of amino acids : | MEEKQILCVG LVVLDVISLV DKYPKEDSEI RCLSQRWQRG GNASNSCTIL SLLGAPCAFM GSMAPGHVAD FVLDDLRRYS VDLRYTVFQT TGSVPIATVI INEASGSRTI LYYDRSLPDV SATDFEKVDL TQFKWIHIEG RNASEQVKML QRIDAHNTRQ PPEQKIRVSV EVEKPREELF QLFGYGDVVF VSKDVAKHLG FQSAEEALRG LYGRVRKGAV LVCAWAEEGA DALGPDGKLL HSDAFPPPRV VDTLGAGDTF NASVIFSLSQ GRSVQEALRF GCQVAGKKCG LQGFDGIV |
Form : | Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol |
Molecular Weight : | 32.7 kDa (298aa) |
Purity : | > 90% by SDS - PAGE |
Concentration : | 1 mg/ml (determined by Bradford assay) |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Pathways : | Fructose and mannose metabolism; Metabolic pathways; Metabolism of carbohydrates |
Gene Name : | KHK ketohexokinase (fructokinase) [ Homo sapiens ] |
Synonyms : | KHK; ketohexokinase (fructokinase); ketohexokinase; EC 2.7.1.3; ketohexokinase; Hepatic fructokinase; |
Gene ID : | 3795 |
mRNA Refseq : | NM_000221 |
Protein Refseq : | NP_000212 |
MIM : | 229800 |
UniProt ID : | P50053 |
Chromosome Location : | 2p23.3 |
Function : | ATP binding; ketohexokinase activity; kinase activity; nucleotide binding; protein binding; transferase activity |
Products Types
◆ Recombinant Protein | ||
Khk-1263M | Recombinant Mouse Khk Protein, MYC/DDK-tagged | +Inquiry |
KHK-4800M | Recombinant Mouse KHK Protein, His (Fc)-Avi-tagged | +Inquiry |
KHK-2902R | Recombinant Rat KHK Protein, His (Fc)-Avi-tagged | +Inquiry |
KHK-747Z | Recombinant Zebrafish KHK | +Inquiry |
KHK-8613M | Recombinant Mouse KHK Protein | +Inquiry |
◆ Lysates | ||
KHK-4985HCL | Recombinant Human KHK 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (6)
Ask a questionActivity of KHK protein is affected by many factors, including gene expression, hormone levels, nutritional status, etc. In addition, some small molecule compounds can also regulate the activity of KHK proteins.
Some studies have shown that abnormal expression of the KHK protein may be related to the occurrence and progression of some diseases. For example, in some cancers, the expression level of the KHK protein may change. In addition, the KHK protein may also be a drug target for the treatment of these diseases.
The activity of the KHK protein can be modulated by drugs or other small molecule compounds to treat diseases related to the KHK protein. For example, some drugs can inhibit the activity of the KHK protein to treat diseases associated with abnormal metabolism of ketone bodies
Some studies have shown that mutations or abnormal expression of the KHK protein may be related to some diseases, such as cancer, neurodegenerative diseases, etc. However, the specific association needs to be confirmed by further research.
The interaction between the KHK protein and other enzymes or proteins is complex. For example, it may interact with fatty acid synthase to co-catalyze the synthesis of ketone bodies. In addition, it may interact with some regulators to regulate its activity.
The occurrence, progression, and prognosis of the disease can be assessed by examining the expression level, activity, and interaction of KHK protein with other proteins. These features can also be used to develop new biomarkers and drug targets.
Customer Reviews (3)
Write a reviewDue to the short half-life and high clearance characteristics of KHK, they can better adapt to the treatment needs of patients of different ages, providing patients with a safer and more effective treatment option.
The stability of KHK is so good that it can be manipulated experimentally for long periods of time without compromising its performance and results.
Reproducibility of the Western blot was significantly improved by using this protein.
Ask a Question for All KHK Products
Required fields are marked with *
My Review for All KHK Products
Required fields are marked with *
Inquiry Basket