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Recombinant Human metallopeptidase inhibitor 1, His-tagged

Cat.No. : TIMP1-287H
Product Overview : Recombinant Human TIMP-1 comprises a 184 amino acid fragment (24-207) corresponding to the mature TIMP-1 protein and is expressed inE. coliwith an aminoterminal hexahistidine tag.
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Cat. No. : TIMP1-287H
Description : TIMP-1 is an inducible glycoprotein, which is synthesized by many different cell types. TIMP-1 binds in a reversible fashion to matrix metalloproteinases, with regions in the N-terminal domain binding to the MMP substrate-binding site. TIMP-1 also functions as erthyroid-potentiating activity via translocation to the nucleus and also in inhibiting apoptosis in B-cells.
Source : E.coli.
Purity : >95% by SDS-PAGE
Form : Liquid
Storage : Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.
Gene Name : TIMP1 TIMP metallopeptidase inhibitor 1 [ Homo sapiens ]
Synonyms : CLGI; EPA, EPO; HCI; TIMP; Erythroid-potentiating activity; tissue inhibitor of metalloprotease 1; collagenase inhibitor; metalloprotease inhibitor 1 precursor; tissue inhibitor of metalloproteases; FLJ90373; OTTHUMP00000023214; TIMP-1; Collagenase inhibitor; Erythroid-potentiating activity; TIMP metallopeptidase inhibitor 1; erythroid potentiating activity; tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor); tissue inhibitor of metalloproteinase 1; erythroid potentiating activity; fibroblast collagenase inhibitor.
Gene ID : 7076
mRNA Refseq : NM_003254
Protein Refseq : NP_003245
MIM : 305370
UniProt ID : P01033
Chromosome Location : Xp11.3-p11.23
Function : enzyme inhibitor activity; metalloendopeptidase inhibitor activity; protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What are the molecular consequences of dysregulated TIMP1 expression in cancer progression? 01/06/2022

Dysregulated TIMP1 expression in cancer can disrupt the balance between MMPs and TIMPs, contributing to excessive extracellular matrix degradation, invasion, and metastasis.

Can you explain the molecular role of TIMP1 in the inhibition of metalloproteinases? 06/30/2020

TIMP1 inhibits metalloproteinases by forming a complex with them, blocking their active sites and preventing the degradation of extracellular matrix components.

How does the nuclear localization of FXN contribute to its role in cellular processes? 03/02/2020

FXN's nuclear localization is associated with its involvement in DNA repair processes, influencing genomic stability and contributing to the overall cellular response to stress.

Can you explain the interplay between TIMP1 and the immune system in inflammatory processes? 07/13/2019

TIMP1 has immunomodulatory effects, influencing inflammation by regulating immune cell migration, cytokine production, and interactions with the extracellular matrix.

What is the significance of TIMP1 in tissue homeostasis and repair? 10/19/2018

TIMP1 plays a crucial role in tissue homeostasis and repair by controlling the activity of MMPs, which are involved in remodeling the extracellular matrix during physiological and pathological processes.

Customer Reviews (3)

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Reviews
04/16/2021

    The efficient delivery of this product ensured that our research timelines were met without any complications.

    08/03/2020

      Impressed by the professionalism of the customer service team—responsive and knowledgeable about the entire product range.

      12/08/2018

        This recombined protein has become a go-to in our lab due to its reliability and the precision it brings to our experiments.

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