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Recombinant Human NOG protein

Cat.No. : NOG-21H
Product Overview : Recombinant Human NOG protein was expressed in Escherichia coli.
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  • Gene Information
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Description : Noggin encoded by the NOG gene, was first isolated from Xenopus, having the function of inducing secondary axis formation in frog embryos. It inhibits TGF-β family ligands and preventing them from binding to their corresponding receptors. Noggin was originally found as a BMP-4 antagonist, and then has been shown to modulate the activities of other BMPs (BMP-2, 7, 13 and 14). Additionally, it has pleiotropic effect, both in early development and later stages. The results of the mouse knockout of noggin suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. In recent report, proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) have relation with the mutant of evolutionarily conserved amino acid residues of Noggin. Mature human Noggin shares 99 %, 99 %, 98 %, 97 % and 89 % a.a. sequence identity with mouse, rat, bovine, equine and chicken Noggin, respectively.
Source : E.coli
Species : Human
Form : Lyophilized from a 0.2μm filtered concentrated solution in 30 % acetonitrile, 0.1 % TFA.
Bio-activity : Fully biologically active when compared to standard. The ED50 as determined by inhibiting BMP-4-induced alkaline phosphatase production of murine ATDC5 cells is less than 3.0 ng/ml, corresponding to a specific activity of > 3.3 × 10⁵ IU/mg in the presence of 5 ng/ml rHuBMP-4.
Molecular Mass : Approximately 46.3 kDa, non-disulfide-linked homodimer consisting of two 206 amino acid polypeptide chains.
Protein length : 206
AA Sequence : MQHYLHIRPAPSDNLPLVDLIEHPD PIFDPKEKDLNETLLRSLLGGHYDP GFMATSPPEDRPGGGGGAAGGAEDL AELDQLLRQRPSGAMPSEIKGLEFS EGLAQGKKQRLSKKLRRKLQMWLWS QTFCPVLYAWNDLGSRFWPRYVKVG SCFSKRSCSVPEGMVCKPSKSVHLT VLRWRCQRRGGQRCGWIPIQYPIIS ECKCSC
Endotoxin : Less than 1 EU/μg of rHuNoggin as determined by LAL method.
Purity : >95% by SDS-PAGE and HPLC analysis.
Storage : Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution : We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in 10mM HCl to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤-20 centigrade. Further dilutions should be made in appropriate buffered solutions.
Gene Name : NOG
Official Symbol : NOG
Synonyms : NOG; noggin; SYM1, symphalangism 1 (proximal) , synostoses (multiple) syndrome 1 , SYNS1; symphalangism 1 (proximal); SYM1; SYNS1;
Gene ID : 9241
mRNA Refseq : NM_005450
Protein Refseq : NP_005441
MIM : 602991
UniProt ID : Q13253

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does NOG (Noggin) modulate bone morphogenetic protein (BMP) signaling in development and tissue repair? 10/25/2022

NOG inhibits BMP signaling, critical for tissue development and repair processes.

What are the mechanisms by which NOG modulates embryonic patterning and organogenesis? 09/05/2021

NOG modulates embryonic patterning and organogenesis, guiding proper organ development.

How do alterations in NOG expression or function affect the development of congenital anomalies? 02/08/2020

Changes in NOG expression or function can lead to congenital anomalies due to disrupted developmental processes.

How does NOG contribute to the regulation of stem cell differentiation? 07/11/2019

NOG regulates stem cell differentiation, influencing their development into various tissue types.

What role does NOG play in skeletal development and the regulation of bone growth? 02/11/2019

NOG plays a key role in skeletal development by regulating bone growth and differentiation.

How does NOG influence neural development and neurogenesis? 02/03/2019

NOG influences neural development, impacting the formation and specialization of neural cells.

What is the impact of NOG in joint and cartilage health, particularly in arthritis? 01/07/2018

NOG is important for joint and cartilage health, potentially impacting arthritis progression.

Customer Reviews (3)

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Reviews
07/15/2022

    Efficient peptide synthesis, accelerates our peptide research projects.

    04/30/2018

      Fast and reliable protein expression, aids our experiments significantly.

      01/25/2018

        Dependable antibody validation, crucial for our immunoprecipitation studies.

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