Recombinant Human NOG protein
Cat.No. : | NOG-21H |
Product Overview : | Recombinant Human NOG protein was expressed in Escherichia coli. |
- Specification
- Gene Information
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Description : | Noggin encoded by the NOG gene, was first isolated from Xenopus, having the function of inducing secondary axis formation in frog embryos. It inhibits TGF-β family ligands and preventing them from binding to their corresponding receptors. Noggin was originally found as a BMP-4 antagonist, and then has been shown to modulate the activities of other BMPs (BMP-2, 7, 13 and 14). Additionally, it has pleiotropic effect, both in early development and later stages. The results of the mouse knockout of noggin suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. In recent report, proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) have relation with the mutant of evolutionarily conserved amino acid residues of Noggin. Mature human Noggin shares 99 %, 99 %, 98 %, 97 % and 89 % a.a. sequence identity with mouse, rat, bovine, equine and chicken Noggin, respectively. |
Source : | E.coli |
Species : | Human |
Form : | Lyophilized from a 0.2μm filtered concentrated solution in 30 % acetonitrile, 0.1 % TFA. |
Bio-activity : | Fully biologically active when compared to standard. The ED50 as determined by inhibiting BMP-4-induced alkaline phosphatase production of murine ATDC5 cells is less than 3.0 ng/ml, corresponding to a specific activity of > 3.3 × 10⁵ IU/mg in the presence of 5 ng/ml rHuBMP-4. |
Molecular Mass : | Approximately 46.3 kDa, non-disulfide-linked homodimer consisting of two 206 amino acid polypeptide chains. |
Protein length : | 206 |
AA Sequence : | MQHYLHIRPAPSDNLPLVDLIEHPD PIFDPKEKDLNETLLRSLLGGHYDP GFMATSPPEDRPGGGGGAAGGAEDL AELDQLLRQRPSGAMPSEIKGLEFS EGLAQGKKQRLSKKLRRKLQMWLWS QTFCPVLYAWNDLGSRFWPRYVKVG SCFSKRSCSVPEGMVCKPSKSVHLT VLRWRCQRRGGQRCGWIPIQYPIIS ECKCSC |
Endotoxin : | Less than 1 EU/μg of rHuNoggin as determined by LAL method. |
Purity : | >95% by SDS-PAGE and HPLC analysis. |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in 10mM HCl to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤-20 centigrade. Further dilutions should be made in appropriate buffered solutions. |
Gene Name : | NOG |
Official Symbol : | NOG |
Synonyms : | NOG; noggin; SYM1, symphalangism 1 (proximal) , synostoses (multiple) syndrome 1 , SYNS1; symphalangism 1 (proximal); SYM1; SYNS1; |
Gene ID : | 9241 |
mRNA Refseq : | NM_005450 |
Protein Refseq : | NP_005441 |
MIM : | 602991 |
UniProt ID : | Q13253 |
Products Types
◆ Recombinant Protein | ||
NOG-066N | Active Recombinant Human NOG Protein (206 aa) | +Inquiry |
NOG-126H | Recombinant Human NOG Protein, His (Fc)-Avi-tagged | +Inquiry |
Nog-325R | Recombinant Rat Nog Protein, His/MBP-tagged | +Inquiry |
NOG-213N | Active Recombinant Human NOG Protein | +Inquiry |
NOG-2850H | Recombinant Human NOG protein(28-232 aa), N-MBP & C-His-tagged | +Inquiry |
◆ Lysates | ||
NOG-2414HCL | Recombinant Human NOG cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionNOG inhibits BMP signaling, critical for tissue development and repair processes.
NOG modulates embryonic patterning and organogenesis, guiding proper organ development.
Changes in NOG expression or function can lead to congenital anomalies due to disrupted developmental processes.
NOG regulates stem cell differentiation, influencing their development into various tissue types.
NOG plays a key role in skeletal development by regulating bone growth and differentiation.
NOG influences neural development, impacting the formation and specialization of neural cells.
NOG is important for joint and cartilage health, potentially impacting arthritis progression.
Customer Reviews (3)
Write a reviewEfficient peptide synthesis, accelerates our peptide research projects.
Fast and reliable protein expression, aids our experiments significantly.
Dependable antibody validation, crucial for our immunoprecipitation studies.
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