Recombinant Human BTK, GST-tagged
Cat.No. : | BTK-530H |
Product Overview : | Recombinant full-length human BTK was expressed by baculovirus inSf9 insect cellsusing a N-terminal GST tag. MW=106kDa. |
- Specification
- Gene Information
- Related Products
Cat. No. : | BTK-530H |
Description : | BTK (also known as Bruton tyrosine kinase) plays a crucial role in B-lymphocyte differentiation and activation. BTK interacts with SRC homology 3 domains of FYN, LYN and HCK that are activated upon stimulation of B- and T-cell receptors. Defects in the BTK gene cause Agammaglobulinemia, an X-linked immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement. The unique role of BTK makes it a desirable target for potential anti-cancer, anti-inflammatory and anti-viral agents as well as other treatments. |
Source : | Sf9 insect cells using baculovirus. |
Purity : | >80%. |
Specific Activity : | 23 pmol/min/μg. |
Assay condition : | The enzyme reaction wascarried out for 1h at room temperature in abuffer containing 50 mM HEPES (pH7.5),10 mM MgCl2, 1 mM EDTA, 0.01% BRIJ-35 and 200 μM of ATP. Substrate : 2 μM Tyr peptide 1 from Invitrogen. |
Application : | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
Formulated In : | 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 50% glycerol, and 3 mM DTT. |
Stability : | >6 months at –80°C. |
Gene Name : | BTK Bruton agammaglobulinemia tyrosine kinase [ Homo sapiens ] |
Synonyms : | BTK; Bruton agammaglobulinemia tyrosine kinase; AT; ATK; BPK; XLA; IMD1; AGMX1; PSCTK1; MGC126261; MGC126262; OTTHUMP00000023676; OTTHUMP00000063593; Bruton tyrosine kinase; B-cell progenitor kinase; tyrosine-protein kinase BTK; agammaglobulinemia tyrosine kinase; dominant-negative kinase-deficient Brutons tyrosine kinase |
Gene ID : | 695 |
mRNA Refseq : | NM_000061 |
Protein Refseq : | NP_000052 |
MIM : | 300300 |
UniProt ID : | Q06187 |
Chromosome Location : | Xq21.33-q22 |
Pathway : | B cell receptor signaling pathway; Fc epsilon RI signaling pathway |
Function : | ATP binding; identical protein binding; kinase activity; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein tyrosine kinase activity; transferase activity; zinc ion binding |
Products Types
◆ Recombinant Protein | ||
BTK-26220TH | Active Recombinant Human BTK protein | +Inquiry |
BTK-0744H | Recombinant Human BTK Protein (M1-S659), GST tagged | +Inquiry |
BTK-06H | Recombinant Human BTK (R562W) Mutant Protein, GST-tagged | +Inquiry |
BTK-0743H | Recombinant Human BTK Protein (M1-S659), Tag Free | +Inquiry |
BTK-092H | Recombinant Human BTK Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
◆ Lysates | ||
BTK-001HCL | Recombinant Human BTK cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1569 | BTK Kinase Binding Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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