Recombinant Bovine Chemokine (C-C motif) Ligand 5

Cat. No.

CCL5-132B

Product Overview

Recombinant Bovine CCL5 protein was expressed in Yeast and purified by using Ion-exchange chromatography, 7.9 kDa (68 aa).

Description

CCL5 is an 8kDa protein classified as a chemotactic cytokine or chemokine. CCL5 is chemotactic for T cells, eosinophils, and basophils, and plays an active role in recruiting leukocytes into inflammatory sites. With the help of particular cytokines (i.e., IL-2 and IFN-γ) that are released by T cells, CCL5 also induces the proliferation and activation of certain natural-killer (NK) cells to form CHAK (CC-Chemokine-activated killer) cells.

Source

Yeast.

Sequences Of Amino Acids

SPYASDTTPC CFAYISRPLP RTHVQEYFYT SSKCSMAAVV FITRKNRQVC ANPEKKWVRE YINALELS.

Formulation/

Reconstitution

Lyophilized. Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein.

Purity

>95% as visualized by SDS-PAGE analysis.

Purification

Ion-exchange chromatography.

Biological Activity

In testing.

Storage

Stable for up to twelve months from date of receipt at -20^oC. Stable for at least 3 months when stored in working aliquots with a carrier protein at -20^oC. Avoid repeated freeze/thaw cycles.

Gene Information

Gene Name

CCL5 chemokine (C-C motif) ligand 5 [ Bos taurus ]

Synonyms

CCL5; chemokine (C-C motif) ligand 5; RANTES; MGC127014; C-C motif chemokine 5;  SIS-delta; small-inducible cytokine A5; T-cell-specific protein RANTES 

GeneID

327712

mRNA Refseq

NM_175827

Protein Refseq

NP_787021

UniProt ID

O97919

Chromosome Location

19

Pathways

Chemokine signaling pathway; Cytokine-cytokine receptor interaction; Cytosolic DNA-sensing pathway; NOD-like receptor signaling pathway; Prion diseases; Toll-like receptor signaling pathway

Function

chemoattractant activity; chemokine activity