| Cat. No. : |
CCL5-147S |
| Description : |
CCL5 is an 8kDa protein classified as a chemotactic cytokine or chemokine. CCL5 is chemotactic for T cells, eosinophils, and basophils, and plays an active role in recruiting leukocytes into inflammatory sites. With the help of particular cytokines (i.e., IL-2 and IFN-γ) that are released by T cells, CCL5 also induces the proliferation and activation of certain natural-killer (NK) cells to form CHAK (CC-Chemokine-activated killer) cells. |
| Source : |
Yeast. |
| Sequences Of Amino Acids : |
SPYASDTTPC CFSYLSRPLP RAHLQEYFYT SSKCSMAAVV FITRKNRQVC ANPEKKWVRE YINTLEMS. |
| Formulation/ Reconstitution : |
Lyophilized. Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein. |
| Purity : |
>95% as visualized by SDS-PAGE analysis. |
| Purification : |
Ion-exchange chromatography. |
| Biological Activity : |
The biological activity of recombinant swine CCL5 was determined in a chemotaxis assay using a Boyden chamber with freshly isolated swine PBMC monocytes using a Percoll gradient enrichment method. Biological activity typically peaks at 100 ng/mL. |
| Storage : |
Stable for up to twelve months from date of receipt at -20°C. Stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze/thaw cycles. |
| Pathways : |
Chemokine signaling pathway; Cytokine-cytokine receptor interaction; Cytosolic DNA-sensing pathway; NOD-like receptor signaling pathway; Prion diseases; Toll-like receptor signaling pathway |
