Catalog # or name ...
ADAMTS-1 (residues 253 to 617 of full-length human ADAMTS-1) with
his tag protein, was expressed in a baculovirus system and purified
from insect cells, 50 kDa.
glutamyl-specific multidomain metalloproteinases of the ADAMTS (a
disintegrin and metalloproteinase with thrombospondin motifs)
family. They hydrolyze aggrecan, the major proteoglycan of articular
cartilage, causing osteoarthritis and other joint diseases. ADAMTS-1
has also been shown to cleave versican, which is the principal large
proteoglycan expressed in mid-tendon.
Activity (mU/mg) is
specified on the vial.
One milliunit of
protease hydrolyzes 1 nanomole of aggrecan interglobular domain
substrate per minute at pH 7.5 at 37oC.
> 90% as estimated
50 mM Tris-HCl, pH
7.5, 150 mM NaCl, 5 mM CaCl2, 0.05% Brij-35.
Used as a positive
control in FRET-based and aggrecan enzyme activity assays, Western
blot, IP, and ELISA.
Store at -80oC.
Avoid multiple thaw-freeze cycles.
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 [
Homo sapiens ]
KIAA1346; ADAMTS1;ADAM metallopeptidase with thrombospondin type 1
motif, 1; a disintegrin and metalloproteinase with thrombospondin
motifs 1; METH-1;ADAM-TS1;ADAMTS-1;ADAM-TS 1;human metalloproteinase
with thrombospondin type 1 motifs; a disintegrin-like and
metalloprotease (reprolysin type) with thrombospondin type 1 motif,
1; EC 3.4.24.-
metal ion binding; metalloendopeptidase activity; metallopeptidase
activity; peptidase activity; protein binding; zinc ion binding
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