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Active Recombinant Human ADAMTS1, His-tagged

Cat.No. : ADAMTS1-532H
Product Overview : Recombinant human ADAMTS-1 (residues 253 to 617 of full-length human ADAMTS-1) with his tag protein, was expressed in abaculovirussystem and purified from insect cells, 50 kDa.
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  • Gene Information
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Cat. No. : ADAMTS1-532H
Description : Aggrecanases are glutamyl-specific multidomain metalloproteinases of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. They hydrolyze aggrecan, the major proteoglycan of articular cartilage, causing osteoarthritis and other joint diseases. ADAMTS-1 has also been shown to cleave versican, which is the principal large proteoglycan expressed in mid-tendon.
Source : Baculovirus.
Activity : Activity (mU/mg) is specified on the vial.
Unit Definition : One milliunit of protease hydrolyzes 1 nanomole of aggrecan interglobular domain substrate per minute at pH 7.5 at 37°C.
Purity : > 90% as estimated by SDS-PAGE.
Formulation : 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 5 mM CaCl2, 0.05% Brij-35.
Application : Used as a positive control in FRET-based and aggrecan enzyme activity assays, Western blot, IP, and ELISA.
Storage : Store at -80°C. Avoid multiple thaw-freeze cycles.
Gene Name : ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 [ Homo sapiens ]
Synonyms : C3-C5; METH1; KIAA1346; ADAMTS1;ADAM metallopeptidase with thrombospondin type 1 motif, 1; a disintegrin and metalloproteinase with thrombospondin motifs 1; METH-1;ADAM-TS1;ADAMTS-1;ADAM-TS 1;human metalloproteinase with thrombospondin type 1 motifs; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1; EC 3.4.24.-
Gene ID : 9510
mRNA Refseq : NM_006988
Protein Refseq : NP_008919
MIM : 605174
UniProt ID : Q9UHI8
Chromosome Location : 21q21.2
Function : heparin binding; metal ion binding; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; protein binding; zinc ion binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (11)

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What is the structure domain of ADAMTS1? 11/10/2022

Pro-peptide, metallo proteinase, depolymerase/cysteine enriched region, spacer region and thrombospondin type I repeat.

My customization requirements are not listed on the page, can it be customized? 08/10/2022

Yes, you can first communicate with our experts for customized requirements.

Is it also possible to shorten the lead time for custom-manufactured proteins? 03/11/2022

The delivery cycle of this kind of protein is related to your specific customization requirements, you can communicate with our experts first.

Do you offer ADAMTS1 protein fused with other tags? 12/14/2021

We can provide ADAMTS1 protein fused with other tags.

Is ADAMTS1 widely used in disease research? 10/16/2021

ADAMTS1 applied to a variety of diseases including colon, oesophageal and lung cancers.

What physiological and pathological processes is ADAMTS1 involved in? 03/06/2021

ADAMTS1 is involved in the physiological and pathological processes of human growth and development, the formation of the urinary and reproductive systems, and the development of tumours in tissues and organs.

What are the consequences of ADAMTS1 inactivation? 01/07/2021

Inactivation of ADAMTS1 causes infertility and developmental delay in females.

Is there a discount for all ADAMTS1 proteins? 12/12/2020

Yes, all ADAMTS1 proteins are currently discounted.

What proteins does ADAMTS1 degrade? 10/26/2020

ADAMTS1 degrades extracellular matrix proteins such as versican , aggrecan , syndecan and nidogen.

I saw that proteins can be customized, can I customize ADAMTS1 for specific bands? 07/15/2019

Yes, our team can customize the protein according to your requirements.

What is the effect of adding trehalose on the preservation of protein? 06/08/2019

Trehalose can prevent protein secondary structure changes, elongation and aggregation during freeze-drying.

Customer Reviews (3)

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Reviews
03/01/2021

    Excellent after-sales service, solving many experimental problems.

    06/30/2020

      The products provided by your company are inexpensive and of high quality, and because of this, my experiments could be completed successfully.

      09/03/2019

        The price of the product is right and the quality meets my research needs.

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