Active Recombinant Human ADAMTS4, His-tagged
Cat.No. : | ADAMTS4-533H |
Product Overview : | Recombinant human ADAMTS-1 (residues 213 to 579 of full-length human ADAMTS-4) protein with His tag, was expressed in abaculovirussystem and purified from insect cells, 40 kDa. |
- Specification
- Gene Information
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Cat. No. : | ADAMTS4-533H |
Description : | Aggrecanases belong to a family of ADAMTS proteases (ADAMTS = A disintegrin and metalloprotease with thrombospondin motifs). ADAMTS enzymes are comprised of an N-terminal prodomain, a catalytic domain, a disintegrin domain, one or more thrombospondin (TS) motifs, a cysteine-rich domain and a spacer domain of variable length. The prodomains are cleaved off intracellularly and the enzymes are processed further from their C-terminal ends after secretion. Aggrecanases are responsible for aggrecan degradation in osteoarthritic joints. ADAMTS-4 (aggrecanase-1) is a major aggrecanase in human osteoarthritic cartilage.5 ADAMTS-4 hydrolyzes also versican and brevican. |
Source : | Baculovirus. |
Activity : | Activity (mU/mg) is specified on the vial. |
Unit Definition : | One milliunit of protease hydrolyzes 1 nanomole of aggrecan interglobular domain substrate per minute at pH 7.5 at 37°C. |
Purity : | > 90% as estimated by SDS-PAGE. |
Formulation : | 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 5 mM CaCl2, 0.05% Brij-35. |
Application : | Used for screening of ADAMTS-4 inhibitors and for continuous assay of ADAMTS-4 activity and for FRET-based assay. |
Storage : | Store at -80°C. Avoid multiple thaw-freeze cycles. |
Gene Name : | ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 [ Homo sapiens ] |
Synonyms : | ADAM metallopeptidase with thrombospondin type 1 motif, 4; ADMP-1; ADAMTS-2; ADAMTS-4; KIAA0688; ADAMTS4; a disintegrin and metalloproteinase with thrombospondin motifs 4; ADAM-TS4; ADAM-TS 4; aggrecanase-1; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4; EC 3.4.24.82 |
Gene ID : | 9507 |
mRNA Refseq : | NM_005099 |
Protein Refseq : | NP_005090 |
MIM : | 603876 |
UniProt ID : | O75173 |
Chromosome Location : | 1q21-q23 |
Function : | metal ion binding; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; protease binding; zinc ion binding |
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◆ Lysates | ||
ADAMTS4-9029HCL | Recombinant Human ADAMTS4 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionADAMTS4 is an inflammatory factor secreted by macrophages.
IL-1β can induce ADAMTS4 expression.
ADAMTS4 is expressed in the heart, joint tissues, lungs, and other sites.
ADAMTS4 is involved in the degradation of multifunctional proteoglycans in the vascular wall.
ADAMTS4 could be used in research into diseases such as colorectal and gastric cancer.
Customer Reviews (3)
Write a reviewProfessional personnel to provide after-sales service, experimental results are guaranteed.
High protein concentration, good quality, worth buying.
The technicians were very professional and suggested improvements to my experimental program, which allowed the experiment to go smoothly.
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