| Cat. No. | CABT-49802HM |
| Antigen Description | DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family.It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication. |
| Product Overview | HAMSTER ANTI MOUSE DELTA-LIKE PROTEIN 1 |
| Immunogen | DLL1-expressing CHO cells. |
| Isotype | IgG |
| Specificity | CABT-49802HM specifically recognises Delta-like protein 1 (DLL1), one of the five major ligands of the Notch signaling pathway, which is activated through the binding of specific ligands to the Notch receptors Notch 1-4.The Notch signaling pathway is an evolutionarily conserved pathway in multi-cellular organisms, which is vital for cell-cell communication, important during fundamental developmental and physiological processes, including regulation of cell fate decisions during neuronal, cardiac and endocrine development, stem cell hematopoiesis, thymic T-cell development, and both tumor progression and suppression. Ligation of Notch receptors by their specific ligands, Jagged1 (CD339), Jagged2, Delta-like protein 1 (DLL1), DLL3 and DLL4, on physically adjacent signal receiving cells, induces proteolysis of the receptors by ADAM-family metalloproteases and the gamma-secretase complex, within the transmembrane domain, releasing the Notch intracellular domain (NICD) to translocate to the nucleus. Subsequent signal transduction then occurs through either the CSL-NICD-Mastermind complex cascade (canonical pathway), or NF-kappaB-NICD and CSL-NICD-Deltex complex signaling cascades (non-canonical pathway). The canonical pathway inhibits the differentiation of stem cells or progenitor cells, whilst the non-canonical pathway promotes differentiation. DLL1 is widely expressed, and acts as a mediator of cell fate decisions during hematopoiesis, and may play a role in cell-to-cell communication in mammalian embryos. DLL1 plays an important role in B and T cell differentiation, in embryonic somite formation and patterning, and associates with the scaffolding protein MAGI1 at adherens junctions on neuronal processes. Signaling through DLL1 and Notch 2 has been implicated in the development of marginal zone B cells (MZB). Clone HMD1-5 has been shown to cross-react with rat mast cell line RBL-2H3 in flow cytometry. |
| Application | Flow Cytometry Immunohistology - Frozen Functional Assays |
| Form | Purified IgG - liquid |
| Storage Buffer | Store at +4oC or at -20oC if preferred.Storage in frost-free freezers is not recommended.This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. |
| Buffer Stabilisers | Buffer Solution:Phosphate buffered saline
Preservative Stabilisers:0.09% Sodium Azide (NaN3) |
| Reactivity | Mouse |
| Preparation | Purified IgG prepared by affinity chromatography on Protein G |
| Shelf Life | 18 months from date of despatch. |
| Clone | INE2-6 |
| Host | Hamster |
| Antigen Gene Information | Gene Name | Dll1 delta-like 1 (Drosophila) [ Mus musculus ] |
| Official symbol | Dll1 |
| Synonyms | Dll1; Delta1; delta-like protein 1 |
| GeneId | 13388 |
| Pathway | Delta-Notch Signaling Pathway, organism-specific biosystem |
| Function | Notch binding; Notch binding; calcium ion binding; protein binding |
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