Recombinant Human SIRT7, His-tagged

• Cat.No.: SIRT7-585H
• Product Overview: Full length (2-400aa) recombinant Human SIRT7 expressed inE.coliN-terminal was fused to his-tagged SIRT7. MW = 49.3 kDa.

Specification

• Cat. No.: SIRT7-585H
• Description: The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group. There are seven human sirtuins, which have been designated SIRT1-SIRT7. Recently, SIRT7 has been shown to activate transcription of RNA polymerase I and deacetylate p53. SIRT7 prevents progressive functional deterioration of the heart, and is suggested to play an important role in regulation of stress responses and cell death in the heart.
• Source: E.coli.
• Purity: ≥85%.
• Formulation: 50 mM sodium phosphate, pH 7.2, containing 100 mM sodium chloride, 5 mM DTT, and 20% glycerol.
• Stability: ≥6 months at -80°C; avoid freeze/thaw cycles by aliquoting the protein and storing at -80°C.

Gene Information

• Gene Name: SIRT7 sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae) [ Homo sapiens ]
• Synonyms: SIRT7; sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae); SIR2L7; MGC126840; MGC126842; NAD-dependent deacetylase sirtuin-7; sirtuin type 7; SIR2-like protein 7; sir2-related protein type 7; silent mating type information regulation 2, S.cerevisiae, homolog 7; EC 3.5.1.-; sirtuin 7
• Gene ID: 51547
• mRNA Refseq: NM_016538
• Protein Refseq: NP_057622
• MIM: 606212
• UniProt ID: Q9NRC8
• Chromosome Location: 17q25
• Function: NAD binding; hydrolase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; metal ion binding; protein binding; zinc ion binding