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Recombinant Rat Apoptotic Peptidase Activating Factor 1, His-tagged

Cat.No. : Apaf1-2062R
Product Overview : Recombinant rat full-length Apaf-1 produced inE. coliis fused with a C-terminal His-tag.
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  • Gene Information
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Cat. No. : Apaf1-2062R
Description : Apoptotic protease activating factor 1, also known as APAF1, is a human homolog of C. elegans CED-4 gene. APAF-1 and CED-4 homologs were found in all currently sequenced animal genomes.
Source/Host : E. coli.
Purity : ~95% (SDS-PAGE).
Formulation : Liquid. In 20mM TRIS-HCl, pH 8.5.
Concentration : 0.25mg/ml.
Short Term Storage : -20°C.
Long Term Storage : -80°C.
Use/Stability : Stability at -20°C: 1-2 weeks.
Handling : Avoid freeze/thaw cycles.
Gene Name : Apaf1 apoptotic peptidase activating factor 1 [ Rattus norvegicus ]
Synonyms : apoptotic peptidase activating factor 1; Apaf1; apoptotic protease-activating factor 1; apaf-1
Gene ID : 78963
mRNA Refseq : NM_023979
Protein Refseq : NP_076469
UniProt ID : Q9EPV5
Chromosome Location : 7q13
Pathway : Alzheimer"s disease; Amyotrophic lateral sclerosis (ALS); Apoptosis; Huntington"s disease; Parkinson"s disease; Small cell lung cancer; p53 signaling pathway
Function : apoptotic protease activator activity; ATP binding; identical protein binding; nucleotide binding; peptidase activity; protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (20)

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What is the biological function of APAF1 ? 12/16/2022

Recombinant APAF1 protein is an important apoptosis-promoting factor that can play a key role in programmed apoptosis.

Are there any side effects of APAF1 ? 11/15/2022

APAF1 is almost non-toxic side effects, will not cause great harm to the human body.

Can APAF1 replace existing antitumor drugs? 10/18/2022

Recombinant APAF1 protein cannot completely replace existing anti-tumor drugs, but it can be used as an important part of comprehensive tumor therapy, which plays an important role in improving the therapeutic effect and reducing the toxic side effects of dose.

What is the latest progress in the clinical application of APAF1 ? 09/02/2022

The latest research shows that the APAF1 can be used as a target of novel tumor immunotherapy, and has a good effect on tumor treatment.

Does recombinant APAF1 have a role in human ER stress response? 06/21/2022

Recombinant APAF1 protein plays an important role in human endoplasmic reticulum stress response and can protect the maintenance of endoplasmic reticulum function by inhibiting apoptosis.

How to prepare APAF1 ? 01/20/2022

APAF1 can be prepared by gene recombination technology, which first expresses the target protein in a large number of expression hosts such as bacteria, and then obtains high purity APAF1 through purification technology.

What is the expression pattern of APAF1 in the human body? 12/20/2021

APAF1 is widely distributed in the human body, expressed not only in tumor cells, but also in many tissues such as heart, liver, and stomach.

What clinical tests and treatments can APAF1 be used for? 11/13/2021

APAF1 can be used in early diagnosis of tumor, prognosis of tumor, and monitoring of tumor therapeutic effect.

Can APAF1 be clearly seen in electron microscope photos? 09/08/2021

The APAF1 has a clear recognition ability for electron microscopy photos, and can be used to observe the effect of specific cells and gene transformations.

What is the relationship between APAF1 and p53 protein? 06/19/2021

APAF1 and p53 are closely related in the activation and regulation of apoptosis pathway.

Can small molecule compounds regulate the expression and activity of APAF1? 06/07/2021

Yes, small molecule compounds have regulatory effects on the expression and activity of APAF1.

What is the antigenicity of APAF1 ? 11/20/2020

APAF1 is low in antigenicity, so it is not easy to produce an immune response.

What is apoptosis resistance? Does APAF1 affect apoptosis resistance? 04/11/2020

Apoptosis resistance is a physical state in which tumor cells overcome the production of apoptotic signals. APAF1 can regulate apoptosis pathway and help to reduce apoptosis resistance.

Does APAF1 have application value in drug dose adjustment? 03/02/2020

Yes, the expression and activity level of APAF1 can be used as a standard for drug dose adjustment, which can play a regulatory role in the effect of tumor therapy.

What is the relationship between APAF1 and liver cancer and breast cancer? 12/26/2019

Recombinant APAF1 protein plays an important role in the development of liver cancer and breast cancer, and can be used as a target for early diagnosis and treatment.

What is the role of APAF1 in tumor resistance? 11/24/2019

APAF1 in tumor resistance may be affected by some factors that can lead to the weakening of apoptotic pathway processes, thus affecting the efficacy of tumor therapy.

Can APAF1 be used to study the relationship between apoptosis and tumor? 11/11/2019

Yes, the recombinant APAF1 protein can be used to study the role and mechanism of apoptosis signaling pathway in tumorigenesis and development.

Which experimental kits can APAF1 be used to prepare? 08/15/2019

APAF1 can be used in Western blot kits, ELISA kits, Western blot kits, etc.

Does APAF1 have potential applications in tumor therapy? 06/13/2019

Yes, recombinant APAF1 protein in tumor therapy can be used to develop novel targeted therapeutic drugs, such as vaccines and immune checkpoint inhibitors.

What is the position and role of APAF1 in apoptosis pathway? 05/15/2019

PAF1 can bind to other apoptotic proteins such as cytochrome c to promote the activation of Karber gene and initiate the apoptotic mechanism.

Customer Reviews (4)

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Reviews
11/11/2021

    This protein is really excellent, every time it is used, it maintains a very stable performance, which can be seen that its production process is very careful.

    10/19/2021

      Short half-life and high clearance properties of AP5Z1 make it an even greater advantage in emergency situations where rapid therapeutic effect is needed.

      04/25/2021

        Green production process of AP5Z1 is very environmentally friendly, from the selection of raw materials to the production process reflects the concept of green production, without any negative impact on the environment.

        02/13/2019

          The repeatability of AP5Z1 can be said to be unmatched, and the results are very consistent in every experiment or application, which is an important reflection of its excellent quality.

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