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Recombinant Mouse Tnfsf5, FLAG-tagged

Cat.No. : Tnfsf5-2077M
Product Overview : Recombinant Mouse Tnfsf5 is produced inHEK 293 Cells. The extracellular domain of mouse CD40L (CD154) (aa 115-260) is fused at the N-terminus to a linker peptide (8 aa) and a FLAG-tag. MW=26kDa.
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Cat. No. : Tnfsf5-2077M
Description : CD154, also called CD40 ligand or CD40L, is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In general, CD40L plays the role of a costimulatory molecule and induces activation in APC in association with T cell receptor stimulation by MHC molecules on the APC. In total CD40L has three binding partners: CD40, α5β1 integrin and αIIbβ3. CD154 is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper IgM syndrome.
Source : HEK 293 Cells.
Purity : ≥90% (SDS-PAGE).
Concentration : 0.1mg/ml after reconstitution.
Formulation : Lyophilized. Contains PBS.
Endotoxin Content : <0.1EU/µg purified protein (LAL test; Bio Whittaker).
Reconstitution : Reconstitute each tube with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
Specificity : Binds to human and mouse CD40.
Biological Activity : Stimulates the proliferation of mouse B cells and dendritic cells. The activity of rmsCD40L increases 1"000-fold (stimulation in the ng/ml range) in the presence of a cross-linking enhancer.
Storage : -20°C.
Gene Name : Cd40lg CD40 ligand [ Mus musculus ]
Synonyms : Cd40lg; CD40 ligand; IGM; IMD3; Ly62; TRAP; gp39; CD154; Cd40l; HIGM1; Ly-62; T-BAM; Tnfsf5; OTTMUSP00000019349; tumor necrosis factor (ligand) superfamily, member 5
Gene ID : 21947
mRNA Refseq : NM_011616
Protein Refseq : NP_035746
UniProt ID : P27548
Chromosome Location : X A5; X 18.0 cM
Pathway : Allograft rejection; Asthma; Autoimmune thyroid disease; Cell adhesion molecules (CAMs); Cytokine-cytokine receptor interaction; Primary immunodeficiency; Systemic lupus erythematosus; T cell receptor signaling pathway
Function : cytokine activity; tumor necrosis factor receptor binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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