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Recombinant Human TNFRSF6B, Fc Chimera

Cat.No. : TNFRSF6B-2078H
Product Overview : Recombinant Human TNFRSF6B is produced inHEK 293 Cells.The extracellular domain of human DcR3 (decoy receptor 3) (aa 1-246) is fused to the Fc portion of human IgG1. MW=58kDa.
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  • Gene Information
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Cat. No. : TNFRSF6B-2078H
Description : This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Overexpression of this gene has been noted in gastrointestinal tract tumors, and it is located in a gene-rich cluster on chromosome 20, with other potentially tumor-related genes. Two transcript variants encoding the same isoform, but differing in the 5" UTR, have been observed for this gene.
Source : HEK 293 Cells.
Concentration : 1mg/ml after reconstitution.
Formulation : Lyophilized. Contains PBS.
Endotoxin Content : <0.1EU/µg purified protein (LAL test; Bio Whittaker).
Reconstitution : Reconstitute with 50µl sterile water.
Specificity : Binds human LIGHT. Does not bind human FasL.
Application : Detection of human LIGHT and TL1A (VEGI) in combination with PAb to human IgG1.
Purity : ≥90% (SDS-PAGE).
Storage : Stable for at least 6 months after receipt when stored at -20°C. Avoid freeze/thaw cycles.
Gene Name : TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy [ Homo sapiens ]
Synonyms : TNFRSF6B; tumor necrosis factor receptor superfamily, member 6b, decoy; M68; TR6; DCR3; DJ583P15.1.1; TNFRSF6B; tumor necrosis factor receptor superfamily member 6B; decoy receptor 3; decoy receptor for Fas ligand
Gene ID : 8771
mRNA Refseq : NM_003823
Protein Refseq : NP_003814
MIM : 603361
UniProt ID : O95407
Chromosome Location : 20q13.3
Pathway : Cytokine-cytokine receptor interaction
Function : protein binding; receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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