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Recombinant Human Caspase 4, Apoptosis-related Cysteine Peptidase

Cat.No. : CASP4-599H
Product Overview : Recombinant Human CASP4 was produced inE. coli.
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Cat. No. : CASP4-599H
Description : Caspase-4 is a member of the caspase family of cysteine proteases. It exists in cells as an inactive pro-enzyme. The pro-enzyme is matured by proteolysis to yield large and small subunits. The active enzyme is a heterotetramer consisting of two large and two small subunits. The expressed caspase-4 spontaneously undergoes auto-processing to yield subunits characteristic of the native enzyme. The active caspase-4 is routinely tested for its ability to enzymatically cleave the substrate WEHD-AFC or WEHD-pNA.
Source : E. coli.
Purity : ≥95% (SDS-PAGE).
Formulation : Lyophilized.
Reconstitution : Reconstitute with PBS containing 15% glycerol to 1U/µl.
Specific Activity : ~5"000U/mg protein. One unit is defined as the amount of enzyme that cleaves 1nmol of the caspase substrate WEHD-pNA per hour at 37°C in reaction solution containing 50mM HEPES, pH 7.2, 50mM NaCl, 0.1% CHAPS, 10mM EDTA, 5% glycerol and 10mM DTT.
Application : Useful in screening caspase inhibitors, studying enzyme regulation and kinetics, determining target substrate or as a positive control in caspase activity assays. We recommend using 1 unit per assay for analyzing caspase activity.
Storage : Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80℃.
Gene Name : CASP4 caspase 4, apoptosis-related cysteine peptidase [ Homo sapiens ]
Synonyms : CASP4; caspase 4, apoptosis-related cysteine peptidase; TX; ICH-2; Mih1/TX; ICEREL-II; ICE(rel)II; caspase-4; CASP-4; ICE(rel)-II; protease TX; protease ICH-2; apoptotic cysteine protease Mih1/TX; caspase 4, apoptosis-related cysteine protease; EC 3.4.22.57;TX protease; Caspase-4 subunit 1; Caspase-4 subunit 2; ICH2
Gene ID : 837
mRNA Refseq : NM_001225
Protein Refseq : NP_001216
MIM : 602664
UniProt ID : P49662
Chromosome Location : 11q22.2-q22.3
Function : cysteine-type endopeptidase activity; peptidase activity; protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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How is CASP4 protein linked to sepsis? 07/01/2020

CASP4 protein is involved in the recognition of bacterial lipopolysaccharide (LPS) and the initiation of the inflammatory response, which can contribute to the development of sepsis.

How does CASP4 protein interact with other proteins in the inflammatory pathway? 12/19/2019

CASP4 protein interacts with other caspases and inflammatory mediators, contributing to the amplification of the inflammatory response.

How is CASP4 protein involved in inflammation? 07/30/2018

CASP4 protein plays a role in the activation of inflammatory pathways and the production of inflammatory cytokines in response to bacterial infection.

Are there any drugs targeting CASP4 protein in clinical development? 11/10/2017

Several pharmaceutical companies are researching potential inhibitors of CASP4 protein as a strategy for treating inflammatory conditions.

How can CASP4 protein be used as a diagnostic biomarker? 09/18/2017

Elevated levels of CASP4 protein in the blood may indicate the presence of inflammation or infection, and could be used as a diagnostic marker for such conditions.

Customer Reviews (3)

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09/03/2017

    By relying on the CASP4 protein and the manufacturer's exceptional technical support, researchers can confidently pursue their experimental goals while knowing they have access to reliable resources and expert guidance.

    08/05/2016

      Its reliable and accurate performance ensures dependable results, contributing to the advancement of scientific knowledge in various disciplines.

      06/28/2016

        In addition to their expertise, the manufacturer's technical support team can assist in troubleshooting and optimizing the handling and application of the CASP4 protein.

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