Recombinant Human Caspase 4, Apoptosis-related Cysteine Peptidase
Cat.No. : | CASP4-599H |
Product Overview : | Recombinant Human CASP4 was produced inE. coli. |
Unit | |
Price | |
Qty |
- Specification
- Gene Information
- Related Products
Cat. No. : | CASP4-599H |
Description : | Caspase-4 is a member of the caspase family of cysteine proteases. It exists in cells as an inactive pro-enzyme. The pro-enzyme is matured by proteolysis to yield large and small subunits. The active enzyme is a heterotetramer consisting of two large and two small subunits. The expressed caspase-4 spontaneously undergoes auto-processing to yield subunits characteristic of the native enzyme. The active caspase-4 is routinely tested for its ability to enzymatically cleave the substrate WEHD-AFC or WEHD-pNA. |
Source : | E. coli. |
Purity : | ≥95% (SDS-PAGE). |
Formulation : | Lyophilized. |
Reconstitution : | Reconstitute with PBS containing 15% glycerol to 1U/µl. |
Specific Activity : | ~5"000U/mg protein. One unit is defined as the amount of enzyme that cleaves 1nmol of the caspase substrate WEHD-pNA per hour at 37°C in reaction solution containing 50mM HEPES, pH 7.2, 50mM NaCl, 0.1% CHAPS, 10mM EDTA, 5% glycerol and 10mM DTT. |
Application : | Useful in screening caspase inhibitors, studying enzyme regulation and kinetics, determining target substrate or as a positive control in caspase activity assays. We recommend using 1 unit per assay for analyzing caspase activity. |
Storage : | Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80℃. |
Gene Name : | CASP4 caspase 4, apoptosis-related cysteine peptidase [ Homo sapiens ] |
Synonyms : | CASP4; caspase 4, apoptosis-related cysteine peptidase; TX; ICH-2; Mih1/TX; ICEREL-II; ICE(rel)II; caspase-4; CASP-4; ICE(rel)-II; protease TX; protease ICH-2; apoptotic cysteine protease Mih1/TX; caspase 4, apoptosis-related cysteine protease; EC 3.4.22.57;TX protease; Caspase-4 subunit 1; Caspase-4 subunit 2; ICH2 |
Gene ID : | 837 |
mRNA Refseq : | NM_001225 |
Protein Refseq : | NP_001216 |
MIM : | 602664 |
UniProt ID : | P49662 |
Chromosome Location : | 11q22.2-q22.3 |
Function : | cysteine-type endopeptidase activity; peptidase activity; protein binding |
Products Types
◆ Recombinant Protein | ||
CASP4-2594H | Recombinant Human CASP4 Protein, His (Fc)-Avi-tagged | +Inquiry |
CASP4-1244M | Recombinant Mouse CASP4 Protein, His (Fc)-Avi-tagged | +Inquiry |
CASP4-0424H | Recombinant Human CASP4 Protein, GST-Tagged | +Inquiry |
CASP4-01H | Active Recombinant Human CASP4 Protein | +Inquiry |
CASP4-462R | Recombinant Rhesus Macaque CASP4 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
CASP4-7836HCL | Recombinant Human CASP4 293 Cell Lysate | +Inquiry |
CASP4-7837HCL | Recombinant Human CASP4 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionCASP4 protein is involved in the recognition of bacterial lipopolysaccharide (LPS) and the initiation of the inflammatory response, which can contribute to the development of sepsis.
CASP4 protein interacts with other caspases and inflammatory mediators, contributing to the amplification of the inflammatory response.
CASP4 protein plays a role in the activation of inflammatory pathways and the production of inflammatory cytokines in response to bacterial infection.
Several pharmaceutical companies are researching potential inhibitors of CASP4 protein as a strategy for treating inflammatory conditions.
Elevated levels of CASP4 protein in the blood may indicate the presence of inflammation or infection, and could be used as a diagnostic marker for such conditions.
Customer Reviews (3)
Write a reviewBy relying on the CASP4 protein and the manufacturer's exceptional technical support, researchers can confidently pursue their experimental goals while knowing they have access to reliable resources and expert guidance.
Its reliable and accurate performance ensures dependable results, contributing to the advancement of scientific knowledge in various disciplines.
In addition to their expertise, the manufacturer's technical support team can assist in troubleshooting and optimizing the handling and application of the CASP4 protein.
Ask a Question for All CASP4 Products
Required fields are marked with *
My Review for All CASP4 Products
Required fields are marked with *
Inquiry Basket