| Cat. No. | CPBT-65179RH |
| Antigen Description | This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Product Overview | RABBIT ANTI HUMAN IRAK1 (C-TERMINAL) |
| Immunogen | Peptide from C terminus of human IRAK |
| Isotype | Polyclonal IgG |
| Specificity | AHP445 recognises an 80kD serine/threonine protein kinase designated IRAK. IRAK is associated with UL-1 receptor subunits, and mediates as signalling cascade leading to NF-kB activation after IL-1 binding. |
| Application | Immunoprecipitation Western Blotting |
| Form | Purified IgG - liquid |
| Storage Buffer | Store at +4oC or at -20oC if preferred.This product should be stored undiluted.Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. |
| Buffer Stabilisers | Buffer Solution:Phosphate buffered saline
Preservative Stabilisers:0.02%Sodium Azide |
| Reactivity | Human |
| Preparation | Antisera to human IRAK were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared by ion exchange chromatography. |
| Shelf Life | 18 months from date of despatch. |
| Host | Rabbit |
| Antigen Gene Information | Gene Name | IRAK1 interleukin-1 receptor-associated kinase 1 [ Homo sapiens ] |
| Official symbol | IRAK1 |
| Synonyms | IRAK1; IRAK; pelle; interleukin-1 receptor-associated kinase 1 |
| GeneId | 3654 |
| mRNA Refseq | NM_001025242 |
| Protein Refseq | NP_00102041 |
| MIM | 300283 |
| Uniprot ID | P51617 |
| Chromosome Location | Xq28 |
| Pathway | Activated TLR4 signalling, organism-specific biosystem |
| Function | ATP binding; NF-kappaB-inducing kinase activity; interleukin-1 receptor binding; kinase activity; nucleotide binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein homodimerization activity; protein kinase activity; protein kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase activity; ubiquitin-protein ligase activity |
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