| Cat. No. | CPBT-65789GH |
| Antigen Description | This gene belongs to the family defined by the mouse resistin-like genes. The characteristic feature of this family is the C-terminal stretch of 10 cys residues with identical spacing. The mouse homolog of this protein is secreted by adipocytes, and may be the hormone potentially linking obesity to type II diabetes. Alternatively spliced transcript variants encoding the same protein have been found for this gene. |
| Product Overview | GOAT ANTI HUMAN RESISTIN |
| Immunogen | Recombinant human resistin. |
| Isotype | Polyclonal IgG |
| Specificity | CPBT-65789GH specifically recognises human resistin, otherwise known as adipose tissue-specific secretory factor, an adipose-derived hormone and member of the resistin/FIZZ family, implicated as a suppressor of the ability of insulin to reduce blood sugar, and to play a role in type 2 diabetes and obesity. Studies have shown that resistin is involved in an increase in the transcription/expression of many pro-inflammatory cytokines, including interleukin-1,-6 and -12, and also upregulates vascular cell-adhesion molecule-1 (VCAM-1), intracellular adhesion molecule-1 (ICAM-1), and monocyte chemotactic protein-1 (MCP-1/CCL2). |
| Application | ELISA Western Blotting |
| Form | Purified IgG - lyophilised |
| Storage Buffer | Prior to reconstitution store at +4oC.After reconstitution store at -20oC.Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. |
| Buffer Stabilisers | Buffer Solution:Phosphate buffered saline
Preservative Stabilisers:None present |
| Reactivity | Human |
| Preparation | Antiserum to human resistin was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography. |
| Shelf Life | 12 months from date of reconstitution. |
| Host | Goat |
| Antigen Gene Information | Gene Name | RETN resistin [ Homo sapiens ] |
| Official symbol | RETN |
| Synonyms | RETN; ADSF; RSTN; XCP1; FIZZ3; RETN1; MGC126603; MGC126609; resistin |
| GeneId | 56729 |
| mRNA Refseq | NM_001193374 |
| Protein Refseq | NP_00118030 |
| MIM | 605565 |
| Uniprot ID | Q9HD89 |
| Chromosome Location | 19p13.2 |
| Pathway | Adipogenesis, organism-specific biosystem |
| Function | hormone activity; hormone activity |
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