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Recombinant Human AGT, His tagged

Cat.No. : AGT-2181H
Product Overview : Recombinant Human AGT (NP_000020.1) (Met 1-Ala 485), fused with a polyhistidine tag at the C-terminus, was produced in Human Cell.
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  • Gene Information
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Source : HEK293
Species : Human
Tag : His
Form : Lyophilized from sterile 50 mM Tris, pH 8.0.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Molecular Mass : The recombinant human angiotensinogen comprises 463 amino acids and has a calculated molecular mass of 51.2 kDa. As a result of glycosylation, the apparent molecular mass of rh angiotensinogen is approximately 55-60 kDa in SDS-PAGE under reducing conditions.
Protein Length : Met 1-Ala 485
Endotoxin : < 1.0 EU per μg protein as determined by the LAL method.
Purity : > 98 % as determined by SDS-PAGE
Storage : Samples are stable for up to twelve months from date of receipt at -20°C to -80°C
Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) [ Homo sapiens ]
Official Symbol : AGT
Synonyms : AGT; angiotensinogen (serpin peptidase inhibitor, clade A, member 8); SERPINA8; angiotensinogen; alpha 1 antiproteinase; antitrypsin; serpin A8; angiotensin I; angiotensin II; pre-angiotensinogen; alpha-1 antiproteinase, antitrypsin; serine (or cysteine) proteinase inhibitor; ANHU;
Gene ID : 183
mRNA Refseq : NM_000029
Protein Refseq : NP_000020
UniProt ID : P01019

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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How is AGT linked to kidney function? 11/19/2022

AGT is produced and released by the kidneys, and it plays a role in regulating renal blood flow and glomerular filtration rate, thereby impacting overall kidney function.

What is the role of AGT in the renin-angiotensin system? 01/14/2022

AGT is the precursor molecule for angiotensin peptides, including angiotensin I and angiotensin II, which are key regulators of blood pressure, fluid balance, and cardiovascular homeostasis.

How is AGT involved in blood pressure regulation? 10/12/2021

AGT-derived angiotensin II plays a critical role in vasoconstriction, sodium reabsorption, and the regulation of aldosterone secretion, all of which influence blood pressure.

Does AGT have a role in the central nervous system? 08/26/2020

AGT and the renin-angiotensin system have been implicated in the central regulation of blood pressure, fluid balance, and neuroendocrine functions.

How is AGT activated in the renin-angiotensin system? 07/15/2020

AGT is cleaved by the enzyme renin to generate angiotensin I, which is subsequently converted to angiotensin II by the enzyme angiotensin-converting enzyme (ACE).

What factors regulate AGT expression? 06/20/2020

AGT expression is regulated by various factors, including hormones (such as aldosterone and glucocorticoids), cytokines, and environmental stimuli.

How does AGT contribute to inflammation and tissue remodeling? 10/03/2019

AGT and its derivatives, such as angiotensin II, can promote inflammation and tissue remodeling through interactions with receptors and signaling pathways.

What techniques are used to study AGT function and regulation? 03/12/2019

Experimental techniques used to study AGT include molecular biology approaches, gene expression analysis, protein quantification, immunohistochemistry, and animal models.

Can genetic variations in AGT affect disease susceptibility? 08/18/2018

Genetic variations in the AGT gene have been associated with an increased risk of hypertension, cardiovascular diseases, and other conditions influenced by the renin-angiotensin system.

How is AGT involved in pregnancy-related disorders? 06/04/2018

AGT levels and the renin-angiotensin system play a role in regulating blood pressure during pregnancy, and dysregulation can contribute to disorders such as preeclampsia.

Customer Reviews (5)

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Reviews
07/29/2020

    The proteins offering reliable results and contributing to the success of my experiments.

    05/09/2020

      The customer service team was incredibly helpful and responsive to my inquiries.

      10/20/2019

        The product allowed me to access high-quality reagents while staying within my budget.

        08/01/2019

          The ordering process was seamless, and the company's efficient shipping ensured that I received the recombinant proteins promptly and in excellent condition.

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