| Cat. No. | CPBT-66222RH |
| Antigen Description | EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that are encoded by the anhidrotic ectodermal dysplasia (EDA) gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. The protein encoded by this gene specifically binds to EDA-A2 isoform. This protein is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains 3 cysteine-rich repeats and a single transmembrane domain but lacks an N-terminal signal peptide. Multiple alternatively spliced transcript variants have been found for this gene, but some variants lack sufficient support. |
| Product Overview | RABBIT ANTI HUMAN XEDAR |
| Immunogen | Recombinant human XEDAR. |
| Isotype | Polyclonal IgG |
| Specificity | AHP1182 detects human X-linked ectodermal dysplasia receptor (XEDAR), a 33kD type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily. XEDAR is a homologue of the ectodermal dysplasia receptor (EDAR), and binds to an isoform of ectodysplasin termed EDA-A2. Binding of ectodysplasin to XEDAR results in the induction of apoptosis, and is thought to be involved ectodermal organ development. New evidence suggests XEDAR may also be involved in skeletal muscle development.Two predominant isoforms of XEDAR exist; XEDAR-s and XEDAR-L, produced by alternative splicing. |
| Application | Western Blotting |
| Form | Purified IgG - liquid |
| Storage Buffer | Store at +4oC or at -20oC if preferred.Storage in frost-free freezers is not recommended.This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. |
| Buffer Stabilisers | Buffer Solution:Phosphate buffered saline
Preservative Stabilisers:0.02%Sodium Azide |
| Reactivity | Human |
| Preparation | Antisera to XEDAR were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography. |
| Shelf Life | 18 months from date of despatch. |
| Host | Rabbit |
| Antigen Gene Information | Gene Name | EDA2R ectodysplasin A2 receptor [ Homo sapiens ] |
| Official symbol | EDA2R |
| Synonyms | EDA2R; ectodysplasin A2 receptor; XEDAR; EDAA2R; EDA-A2R; TNFRSF27; Tumor necrosis factor receptor superfamily member 27; EDA-A2 receptor; X-linked ectodysplasin-A2 receptor; OTTHUMP00000023448; X-linked ectodysplasin receptor; tumor necrosis factor receptor superfamily member XEDAR |
| GeneId | 60401 |
| mRNA Refseq | NM_021783 |
| Protein Refseq | NP_06855 |
| MIM | 300276 |
| Uniprot ID | Q9HAV5 |
| Chromosome Location | Xq11.1 |
| Pathway | Cytokine-cytokine receptor interaction, organism-specific biosystem |
| Function | protein binding; receptor activity; tumor necrosis factor receptor activity |
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