| Cat. No. | CPBT-66579RA |
| Antigen Description | This gene encodes a precursor protein consisting of arginine vasopressin and two associated proteins, neurophysin 2 and a glycopeptide, copeptin. Arginine vasopressin is a posterior pituitary hormone which is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin 2, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. The precursor is thought to be activated while it is being transported along the axon to the posterior pituitary. Arginine vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. It has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. This hormone can contract smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. Mutations in this gene cause autosomal dominant neurohypophyseal diabetes insipidus (ADNDI). |
| Product Overview | RABBIT ANTI ARGININE VASOPRESSIN |
| Immunogen | Arginine Vasopressin Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 |
| Isotype | Polyclonal IgG |
| Specificity | CPBT-66579RA blocks with the arginine vasopression peptide. Cells are found in the paraventricular and supraoptic nucleus and fibers are found throughout the hypothalmus in rat brain of 4% FA perfused tissue. |
| Application | Immunohistology - Frozen |
| Form | Serum - liquid |
| Storage Buffer | Store at +4oC or at -20oC if preferred.This product should be stored undiluted.Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. |
| Buffer Stabilisers | Buffer Solution:Phosphate buffered saline
Preservative Stabilisers:0.09%Sodium Azide |
| Preparation | Antisera to Arginine Vasopressin were raised by repeated immunisation of rabbits with highly purified antigen. Whole serum is supplied - diluted. |
| Shelf Life | 18 months from date of despatch. |
| Host | Rabbit |
| Antigen Gene Information | Gene Name | Avp arginine vasopressin [ Rattus norvegicus ] |
| Official symbol | Avp |
| Synonyms | arginine vasopressin; AVRP; VP; antidiuretic hormone; ADH; neurohypophyseal; ARVP; vasopressin-neurophysin 2-copeptin; vasopressin-neurophysin II-copeptin; AVP-NPII; OTTHUMP00000030089 |
| GeneId | 24221 |
| Pathway | Aquaporin-mediated transport, organism-specific biosystem |
| Function | V1A vasopressin receptor binding; V1A vasopressin receptor binding; V1A vasopressin receptor binding; V1B vasopressin receptor binding; V2 vasopressin receptor binding; caspase inhibitor activity; caspase inhibitor activity; neurohypophyseal hormone activity; neuropeptide hormone activity; neuropeptide hormone activity; protein binding; protein kinase activity; protein kinase activity; signal transducer activity; signal transducer activity |
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