| Cat. No. | CPBT-67450GH |
| Antigen Description | Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. |
| Product Overview | GOAT ANTI HUMAN RADIXIN |
| Immunogen | Peptide sequence C-QARDETKKTQND from the internal region of radixin |
| Isotype | Polyclonal IgG |
| Specificity | CPBT-67450GH specifically recognises human radixin, a barbed end-capping actin-modulating protein and member of the ezrin, radixin, moesin (ERM) protein family, which acts as a linker protein between the plasma membrane and the actin cytoskeleton.Radixin shares high sequence homology with both ezrin and moesin, and studies have shown a high concentration of radixin at cell-to-cell adherens junctions (AJ), and at cleavage furrows during cytokinesis. |
| Application | ELISA Western Blotting |
| Form | Purified IgG - liquid |
| Storage Buffer | Store at +4oC or at -20oC if preferred.Storage in frost-free freezers is not recommended.This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. |
| Buffer Stabilisers | Buffer Solution:TRIS buffered saline
Preservative Stabilisers:0.02% Sodium Azide (NaN3) 0.5% Bovine Serum Albumin |
| Reactivity | Human |
| Preparation | Antiserum to human radixin was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography. |
| Shelf Life | 18 months from date of despatch. |
| Host | Goat |
| Antigen Gene Information | Gene Name | RDX radixin [ Homo sapiens ] |
| Official symbol | RDX |
| Synonyms | radixin; DFNB24; deafness, autosomal recessive 24; OTTHUMP00000233538; OTTHUMP00000233539; OTTHUMP00000233540; OTTHUMP00000233543 |
| GeneId | 5962 |
| mRNA Refseq | NM_002906 |
| Protein Refseq | NP_00289 |
| MIM | 179410 |
| Uniprot ID | P35241 |
| Chromosome Location | 11q23 |
| Pathway | Axon guidance, organism-specific biosystem |
| Function | actin binding; protein binding |
Download Datasheet: |