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Cat.No.
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CPBT-26048GH
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Product Overview
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Goat Polyclonal antibody to Human ABCB5.
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Antigen Description
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ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules (Chen et al., 2005
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Isotype
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IgG
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Immunogen
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Synthetic peptide: C-QTQHRNTSKKAQ, corresponding to internal sequence amino acids 460-471 of Human ABCB5.
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Host
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Goat
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Species
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Human
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Specificity
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Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level). Widely expressed with specific expression in pigment cells. Also expressed in several malignant tissues.
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Formulation
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Liquid
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Purity Detail
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Immunogen affinity purified
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Applications
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Flow Cyt, WB, ELISA
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Storage buffer
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Preservative: 0.02% Sodium Azide Constituents: 0.5% BSA, Tris saline, pH 7.3
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Storage
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Shipped at 4oC. Upon delivery aliquot and store at -20oC. Avoid repeated freeze / thaw cycles.
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Sequence similarities
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Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.Contains 1 ABC transmembrane type-1 domain.Contains 2 ABC transporter domains.
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Antigen Gene Information
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Gene Name
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ABCB5 ATP-binding cassette, sub-family B (MDR/TAP), member 5 [ Homo sapiens ]
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Official Symbol
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ABCB5
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Synonyms
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ABCB5; ATP-binding cassette, sub-family B (MDR/TAP), member 5; ATP-binding cassette sub-family B member 5; ABCB5alpha; ABCB5beta; ATP binding cassette protein; EST422562; P glycoprotein ABCB5; ABCB 5; ABCB5; ABCB5 P-gp; ABCB5_HUMAN; ABCB5alpha; ABCB5beta; ATP binding cassette sub family B (MDR/TAP) member 5; ATP binding cassette sub family B member 5; ATP-binding cassette sub-family B member 5; EST422562; P glycoprotein ABCB5; P-glycoprotein ABCB5; ABCB5 P-gp; P-glycoprotein ABCB5; ATP-binding cassette protein;
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GeneID
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340273
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mRNA Refseq
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NM_001163941
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Protein Refseq
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NP_001157413
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MIM
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611785
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Uniprot ID
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Q2M3G0
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Chromosome Location
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7p14
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Pathway
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ABC transporters, organism-specific biosystem; ABC transporters, conserved biosystem; ABC-family proteins mediated transport, organism-specific biosystem; Transmembrane transport of small molecules, organism-specific biosystem;
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Function
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ATP binding; ATPase activity; ATPase activity, coupled to transmembrane movement of substances; efflux transmembrane transporter activity; nucleotide binding;
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Download Datasheet:
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