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Recombinant Human Phosphofructokinase, Muscle, His-tagged

Cat.No. : PFKM-2362H
Product Overview : Recombinant human PFKM protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. 87.3 kDa (800aa).
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Cat. No. : PFKM-2362H
Description : PFKM is regulatory glycolytic enzymes that convert fructose 6-phosphate and ATP into fructose 1,6-bisphosphate (through PFK-1), fructose 2,6-bisphosphate (through PFK-2) and ADP. Three phosphofructokinase isozymes exist in humans: muscle, liver and platelet. Mutations in this gene have been associated with glycogen storage disease type VII, also known as Tarui disease.
Source : E.coli.
Form : Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 5mM DTT 0.2 M NaCl, and 20% glycerol.
Purity : > 80% by SDS - PAGE.
Concentration : 0.5 mg/ml (determined by Bradford assay).
Sequences Of Amino Acids : MGSSHHHHHH SSGLVPRGSH MTHEEHHAAK TLGIGKAIAV LTSGGDAQGM NA AV RAVVRV GIFTGARVFF VHEGYQGLVD GGDHIKEATW ESVSMMLQLG GT VIG SARCK DFREREGRLR AAYNLVKRGI TNLCVIGGDG SLTGADTFRS EWS DLLS DLQ KAGKITDEEA TKSSYLNIVGLVGSIDNDFC GTDMTIGTDS ALHRIMEIVD AIT TT AQSHQ RTFVLEVMGR HCGYLALVTS LSCGADWVFI PECPPDDDWE EHL CRRLSET RTRGSRLNII IVAEGAIDKN GKPITSEDIK NLVVKRLGYD TRVTVLGHVQ RG GTPSAFDR ILGSRMGVEA VMALLEGTPD TPACVVSLSGNQAVRLPLME CV QVTK DVTK AMDEKKFDEA LKLRGRSFMN NWEVYKLLAH VRPPVSKSGS HTVA VMNVGA PAAGMNAAVR STVRIGLIQG NRVLVVHDGF EGLAKGQIEE AGW SYVG GWT GQGGSKLGTK RTLPKKSFEQ ISANITKFNI QGLVIIGGFE AYTGGLELME GRK QFDELCIPFVVIPATVS NNVPGSDFSV GADTALNTIC TTCDRIKQSA AGTK RRVFII ETMGGYCGYL ATMAGLAAGA DAAYIFEEPF TIRDLQANVEHLVQKMKTTV KRGLVLRNEK CNENYTTDFI FNLYSEEGKG IFDSRKNVLG HMQQGGSPTP FDR NF ATKMG AKAMNWMSGK IKESYRNGRIFANTPDSGCV LGMRKRALVF QPVA ELKDQT DFEHRIPKEQ WWLKLRPILK ILAKYEIDLD TSDHAHLEHI TRKRSGEAAV.
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : PFKM phosphofructokinase, muscle [ Homo sapiens ]
Synonyms : phosphofructokinase, muscle; GSD7; PFK1; PFKA; PFKX; PFK-1; MGC8699; PFKM; 6-phosphofructokinase, muscle type; PFK-A; phosphohexokinase; phosphofructokinase 1; phosphofructokinase-M; 6-phosphofructo-1-kinase; phosphofructo-1-kinase isozyme A; phosphofructokinase, polypeptide X; Phosphofructo-1-kinase isozyme A; PFK-A; Phosphofructokinase 1; Phosphofructokinase-M; Phosphohexokinase; EC 2.7.1.11
Gene ID : 5213
mRNA Refseq : NM_000289
Protein Refseq : NP_000280
MIM : 610681
UniProt ID : P08237
Chromosome Location : 12q13.3
Pathway : Fructose and mannose metabolism; Galactose metabolism; Glycolysis / Gluconeogenesis; Metabolic pathways; Pentose phosphate pathway; Diabetes pathways; Integration of energy metabolism; Metabolism of carbohydrates
Function : 6-phosphofructokinase activity; AMP binding; ATP binding; fructose binding; fructose-6-phosphate binding; identical protein binding; kinase activity; kinase binding; metal ion binding; nucleotide binding; protein C-terminus binding; protein binding; sugar binding; transferase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any known drug interactions involving PFKM-related therapies? 06/27/2019

Drug interactions involving PFKM-related therapies have not been extensively studied, but caution should be exercised in combination with other medications.

Can PFKM mutations be inherited? 11/29/2018

Yes, PFKM deficiency is an autosomal recessive disorder, meaning it can be passed on from both parents.

How can PFKM protein be targeted for therapeutic interventions? 09/17/2018

Targeting PFKM with small molecule inhibitors or gene therapies is being explored as potential treatment strategies.

Can PFKM levels be used as a biomarker for certain diseases? 01/11/2018

PFKM levels have been studied as potential biomarkers for cancer and metabolic disorders, but more research is needed for clinical application.

Are there any known associations between PFKM and cardiovascular diseases? 01/17/2016

Research suggests that PFKM may play a role in cardiac energy metabolism and could be implicated in cardiovascular diseases.

Customer Reviews (3)

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Reviews
09/25/2022

    As a researcher, utilizing PFKM protein in trials offers numerous advantages that contribute to the successful completion of experiments and the acquisition of valuable data.

    03/14/2022

      manufacturers offer customization options, such as alternative conjugation methods or tailored formulations, allowing researchers to optimize PFKM protein to their specific experimental needs.

      06/04/2021

        This ensures the consistency and reproducibility of experimental results, promoting confidence in the obtained data.

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