Recombinant Human SGTA, His-tagged
Cat.No. : | SGTA-2359H |
Product Overview : | Recombinant human SGTA protein, fused to His-tag at C-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. 35.1 kDa (321aa). |
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- Gene Information
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Cat. No. : | SGTA-2359H |
Description : | SGTA, also known as SGT or hSGT, is a ubiquitously expressed protein that contains three TPR protein-protein interaction repeats. This protien is believed to function as a component of the androgen receptor (AR)-chaperone-cochaperone complex, acting as a cochaperone involved in androgen signaling. In addition, SGTA functions as a cochaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity. On the basis of its role in apoptosis and androgen signaling, SGTA is a potential candidate for PCOS (polycystic ovary syndrome), a disorder characterized by androgen excess, obesity and menstrual disturbances. |
Source : | E.coli. |
Form : | Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol 1mM DTT. |
Purity : | > 95% by SDS – PAGE. |
Concentration : | 1 mg/ml (determined by Bradford assay). |
Sequences Of Amino Acids : | MDNKKRLAYA IIQFLHDQLR HGGLSSDAQE SLEVAIQCLE TAFGVTVEDS DLALPQTLPE IFEAAATGKE MPQDLRSPAR TPPSEEDSAE AERLKTEGNE QMKVENFEAA VHFYGKAIEL NPANAVYFCN RAAAYSKLGN YAGAVQDCER AICIDPAYSK AYGRMGLALS SLNKHVEAVA YYKKALELDP DNETYKSNLK IAELKLREAP SPTGGVGSFD IAGLLNNPGF MSMASNLMNN PQIQQLMSGM ISGGNNPLGT PGTSPSQNDL ASLIQAGQQF AQQMQQQNPE LIEQLRSQIR SRTPSASNDD QQELEHHHHH H. |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Gene Name : | SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha [ Homo sapiens ] |
Synonyms : | SGTA; small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha; SGT; hSGT; alphaSGT; small glutamine-rich tetratricopeptide; protein containing three tetratricopeptide repeats |
Gene ID : | 6449 |
mRNA Refseq : | NM_003021 |
Protein Refseq : | NP_003012 |
MIM : | 603419 |
UniProt ID : | O43765 |
Chromosome Location : | 19p13 |
Function : | protein binding |
Products Types
◆ Recombinant Protein | ||
SGTA-5028R | Recombinant Rat SGTA Protein, His (Fc)-Avi-tagged | +Inquiry |
SGTA-8111M | Recombinant Mouse SGTA Protein, His (Fc)-Avi-tagged | +Inquiry |
Sgta-5830M | Recombinant Mouse Sgta Protein, Myc/DDK-tagged | +Inquiry |
SGTA-4000R | Recombinant Rhesus Macaque SGTA Protein, His (Fc)-Avi-tagged | +Inquiry |
SGTA-442Z | Recombinant Zebrafish SGTA | +Inquiry |
◆ Lysates | ||
SGTA-1882HCL | Recombinant Human SGTA 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThere is no conclusive evidence that diet can improve the nutritional status of SGTA protein, but maintaining a balanced diet and moderate protein intake can help maintain good health.
Studies have shown that SGTA protein may be associated with the onset of cardiovascular diseases such as atherosclerosis and myocardial infarction.
The drug development for SGTA is currently in the clinical trial stage, including small molecule inhibitors against SGTA and inhibitors against the SGTA signaling pathway.
Studies have shown that SGTA protein can be involved in the regulation of antiviral immune responses and affect the course of viral infection.
In clinical practice, the expression level of SGTA can be measured to predict the progression and prognosis of the disease, and to guide the choice of treatment regimen. For example, in the diagnosis and treatment of tumor diseases, detecting the expression level of SGTA can help doctors determine the type, stage and prognosis of the disease, and guide the choice of treatment regimen.
At present, there is no direct way to increase the expression level of SGTA protein, but it can be improved by regulating gene expression and providing nutritional support.
Customer Reviews (3)
Write a reviewAround the colleagues are full of praise, the experiment effect is too good.
Very easy to use and highly recommended.
Good activity, can maintain long-term activity.
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