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Recombinant Human Tumor Susceptibility Gene 101, His-tagged

Cat.No. : TSG101-2357H
Product Overview : Recombinant human TSG101 protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. 20.7 kDa (181aa).
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Cat. No. : TSG101-2357H
Description : TSG101(Tumor susceptibility gene 101) protein belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. This protein contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. Mutations and alternative splicing in this protein occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression.
Source : E.coli.
Form : Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 1mM DTT, 10% glycerol.
Purity : > 90% by SDS - PAGE.
Concentration : 0.5 mg/ml (determined by Bradford assay).
Sequences Of Amino Acids : MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMAVS ESQLKKMVSK YKYRDLTVRE TVNVITLYKD LKPVLDSYVF NDGSSRELMNLTGTIPVPYR GNTY NIPICL WLLDTYPYNP PICFVKPTSS MTIKTGKHVD ANGKIYLPYL HEWKHPQSDL LGLIQVMIVV FGDEPPVFSRP.
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : TSG101 tumor susceptibility gene 101 [ Homo sapiens ]
Synonyms : tumor susceptibility gene 101; TSG10; VPS23; TSG101; tumor susceptibility gene 101 protein; tumor susceptibility protein; ESCRT-I complex subunit TSG101; tumor susceptibility gene 10; tumor susceptibility protein
Gene ID : 7251
mRNA Refseq : NM_006292
Protein Refseq : NP_006283
MIM : 601387
UniProt ID : Q99816
Chromosome Location : 11p15
Pathway : Endocytosis
Function : ligand-dependent nuclear receptor transcription coactivator activity; DNA binding; calcium-dependent protein binding; protein binding; small conjugating protein ligase activity; transcription corepressor activity; ubiquitin binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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07/01/2022

    Exemplifying professionalism, the manufacturer excels in delivering truly exceptional quality.

    10/03/2020

      The consistent quality of your protein reagents gives me peace of mind.

      06/13/2020

        My satisfaction knows no bounds when it comes to the peerless quality and performance of this protein reagent.

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