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Cat.No.
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CPBT-26163CH
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Product Overview
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Chicken Polyclonal antibody to Human ADRB2.
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Antigen Description
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This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes.
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Isotype
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IgY
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Immunogen
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Synthetic peptide: DFRIAFQELLC LRRSSLKAYGN GYSSNGNTGE QSGYHVEQEKE NKLLCEDLPGT EDFVGHQGTVP SDNIDSQGRNCS T, corresponding to amino acids 335-408 of Human beta 2 Adrenergic Receptor.
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Host
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Chicken
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Species
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Human
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Formulation
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Liquid
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Purity Detail
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Immunogen affinity purified
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Applications
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ICC/IF, ICC, WB
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Storage buffer
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Preservative: None Constituents: PBS
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Storage
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Shipped at 4oC. Upon delivery aliquot and store at -20oC. Avoid freeze / thaw cycles.
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Sequence similarities
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Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.
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Antigen Gene Information
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Gene Name
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ADRB2 adrenergic, beta-2-, receptor, surface [ Homo sapiens ]
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Official Symbol
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ADRB2
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Synonyms
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ADRB2; adrenergic, beta-2-, receptor, surface; ADRB2R; beta-2 adrenergic receptor; ADRBR; B2AR; BAR; ADRB2; ADRB2_HUMAN; ADRB2R; ADRBR; Adrenergic beta 2 receptor surface; B2AR; BAR; beta 2 adrenoceptor; Beta 2 adrenoreceptor; Beta-2 adrenergic receptor; Beta-2 adrenoceptor; Beta-2 adrenoreceptor; BETA2AR; Catecholamine receptor; OTTHUMP00000160386; OTTHUMP00000160386; beta-2 adrenoceptor; beta-2 adrenoreceptor; catecholamine receptor; BETA2AR;
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GeneID
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154
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mRNA Refseq
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NM_000024
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Protein Refseq
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NP_000015
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Uniprot ID
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P07550
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Chromosome Location
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5q31-q32
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Pathway
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Adrenoceptors, organism-specific biosystem; Amine ligand-binding receptors, organism-specific biosystem; Arf6 signaling events, organism-specific biosystem; Arf6 trafficking events, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem;
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Function
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G-protein coupled receptor activity; adenylate cyclase binding; adrenergic receptor activity; beta2-adrenergic receptor activity; dopamine binding;
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Download Datasheet:
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