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Cat.No.
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CPBT-26222CH
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Product Overview
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Chicken Polyclonal antibody to Human ADSL.
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Antigen Description
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Adenylsuccinate lyase is involved in both de novo synthesis of purines and formation of adenosine monophosphate from inosine monophosphate. It catalyzes two reactions in AMP biosynthesis: the removal of a fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide ribotide (AICA) and removal of fumarate from adenylosuccinate to give AMP. Adenylosuccinase deficiency results in succinylpurinemic autism, psychomotor retardation, and , in some cases, growth retardation associated with muscle wasting and epilepsy. Two transcript variants encoding different isoforms have been found for this gene.
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Isotype
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IgG
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Immunogen
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Full length protein (Human)
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Host
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Chicken
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Species
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Human
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Specificity
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Ubiquitously expressed. Both isoforms are produced by all tissues. Isoform 2 is 10-fold less abundant than isoform 1.
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Formulation
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Liquid
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Purity Detail
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Whole antiserum
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Applications
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WB
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Storage buffer
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Preservative: None Constituents: Whole serum
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Storage
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Shipped at 4oC. Upon delivery aliquot and store at -20oC or -80oC. Avoid repeated freeze / thaw cycles.
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Sequence similarities
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Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
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Antigen Gene Information
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Gene Name
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ADSL adenylosuccinate lyase [ Homo sapiens ]
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Official Symbol
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ADSL
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Synonyms
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ADSL; adenylosuccinate lyase; Adenylosuccinase; Adenylosuccinate lyase; ADSL; AMPS; ASase; ASL; OTTHUMP00000199172; OTTHUMP00000199173; PUR8_HUMAN; adenylosuccinase; ASL; AMPS; ASASE;
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GeneID
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158
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mRNA Refseq
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NM_000026
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Protein Refseq
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NP_000017
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MIM
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608222
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Uniprot ID
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P30566
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Chromosome Location
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22q13.1
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Pathway
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Alanine, aspartate and glutamate metabolism, organism-specific biosystem; Alanine, aspartate and glutamate metabolism, conserved biosystem; Inosine monophosphate biosynthesis, PRPP + glutamine => IMP, organism-specific biosystem; Inosine monophosphate biosynthesis, PRPP + glutamine =>
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Function
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(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity; N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity; NOT N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity; N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity; lyase activity;
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Download Datasheet:
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