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Recombinant Human PTP4A3, 2-173 aa, His-tagged

Cat.No. : PTP4A3-677H
Product Overview : Recombinant human PRL-3 was produced inE. coli.The catalytic domain of PRL-3 (aa 2-173) is fused at the N-terminus to a His-tag. 19.5kDa.
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  • Gene Information
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Cat. No. : PTP4A3-677H
Description : PRL phosphatases comprise a class of small oncogenic phosphatases that are prenylated at their carboxyl-termini. PRL-3 is overexpressed in colon tumors metastasizing to the liver, but not in normal colorectal epithelium. Metastatic lesions have also shown gene amplification of the PRL-3 gene. PRL-3-blocking antibodies reduce metastatic tumor formation by cells overexpressing PRL-3.
Source/Host : E. coli.
Concentration : 0.05μg/μl.
Purity : ≥90% (SDS-PAGE).
Formulation : Liquid. In 25mM TRIS-HCl, pH 8.0, containing 100mM sodium chloride, 0.05% Tween 20, 20% glycerol and 3mM dithiothreitol.
Specific Activity : 0.774U/μg. One unit will hydrolyze 1pmol para-nitrophenyl phosphate (PNPP) per minute at 37°C. Assay buffer: 50mM TRIS, pH 7.4, containing 150mM sodium chloride, 5mM dithiothreitol and 12.5mM PNPP.
Application : Study of enzyme kinetics and regulation, dephosphorylation of target substrates, and inhibitor screening.
Use/Stability : Dilution of the enzyme followed by refreezing may lead to loss of activity.
Long Term Storage : -20°C.
Gene Name : PTP4A3 protein tyrosine phosphatase type IVA, member 3 [ Homo sapiens ]
Synonyms : PTP4A3; protein tyrosine phosphatase type IVA, member 3; PRL3; PRL-3; PRL-R; potentially prenylated protein tyrosine phosphatase; EC 3.1.3.48
Gene ID : 11156
mRNA Refseq : NM_007079
Protein Refseq : NP_009010
MIM : 606449
UniProt ID : O75365
Chromosome Location : 8q24.3
Function : hydrolase activity; identical protein binding; prenylated protein tyrosine phosphatase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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